Long-term effect of combination of creatine monohydrate plus β-hydroxy β-methylbutyrate (HMB) on exercise-induced muscle damage and Anabolic/Catabolic hormones in elite male endurance athletes

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dc.contributor.authorFernández de Landa, Julen
dc.contributor.authorFernández Lázaro, Diego
dc.contributor.authorCalleja González, Julio
dc.contributor.authorCaballero García, Alberto
dc.contributor.authorCórdova Martínez, Alfredo
dc.contributor.authorLeón Guereño, Patxi
dc.contributor.authorMielgo Ayuso, Juan
dc.date.accessioned2025-11-06T13:50:33Z
dc.date.available2025-11-06T13:50:33Z
dc.date.issued2020-01-15
dc.date.updated2025-11-06T13:50:33Z
dc.description.abstractCreatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB) are widely studied ergogenic aids. However, both supplements are usually studied in an isolated manner. The few studies that have investigated the effect of combining both supplements on exercise-induced muscle damage (EIMD) and hormone status have reported controversial results. Therefore, the main purpose of this study was to determine the effect and degree of potentiation of 10 weeks of CrM plus HMB supplementation on EIMD and anabolic/catabolic hormones. This study was a double-blind, placebo-controlled trial where participants (n = 28) were randomized into four different groups: Placebo group (PLG; n = 7), CrM group (CrMG; 0.04 g/kg/day of CrM; n = 7), HMB group (HMBG; 3 g/day of HMB; n = 7), and CrM-HMB group (CrM-HMBG; 0.04 g/kg/day of CrM plus 3 g/day of HMB; n = 7). Before (baseline, T1) and after 10 weeks of supplementation (T2), blood samples were collected from all rowers. There were no significant differences in the EIMD markers (aspartate aminotransferase, lactate dehydrogenase, and creatine kinase) among groups. However, we observed significant differences in CrM-HMBG with respect to PLG, CrMG, and HMBG on testosterone (p = 0.006; η2p = 0.454) and the testosterone/cortisol ratio (T/C; p = 0.032; η2p = 0.349). Moreover, we found a synergistic effect of combined supplementation on testosterone (CrM-HMBG = −63.85% vs. CrMG + HMBG = −37.89%) and T/C (CrM-HMBG = 680% vs. CrMG + HMBG = 57.68%) and an antagonistic effect on cortisol (CrM-HMBG = 131.55% vs. CrMG + HMBG = 389.99%). In summary, the combination of CrM plus HMB showed an increase in testosterone and T/C compared with the other groups after 10 weeks of supplementation. Moreover, this combination presented a synergistic effect on testosterone and T/C and an antagonistic effect on cortisol compared with the sum of individual or isolated supplementation.en
dc.identifier.citationFernández-Landa, J., Fernández-Lázaro, D., Calleja-González, J., Caballero-García, A., Córdova, A., León-Guereño, P., & Mielgo-Ayuso, J. (2020). Long-term effect of combination of creatine monohydrate plus β-hydroxy β-methylbutyrate (HMB) on exercise-induced muscle damage and Anabolic/Catabolic hormones in elite male endurance athletes. Biomolecules, 10(1). https://doi.org/10.3390/BIOM10010140
dc.identifier.doi10.3390/BIOM10010140
dc.identifier.eissn2218-273X
dc.identifier.urihttps://hdl.handle.net/20.500.14454/4299
dc.language.isoeng
dc.publisherMDPI AG
dc.rights© 2020 by the authors
dc.subject.otherMuscle recovery
dc.subject.otherExercise-induced muscle damage
dc.subject.otherLactate dehydrogenase
dc.subject.otherCreatine kinase
dc.subject.otherTestosterone
dc.subject.otherCortisol
dc.subject.otherSport nutrition
dc.subject.otherSupplementation
dc.titleLong-term effect of combination of creatine monohydrate plus β-hydroxy β-methylbutyrate (HMB) on exercise-induced muscle damage and Anabolic/Catabolic hormones in elite male endurance athletesen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue1
oaire.citation.titleBiomolecules
oaire.citation.volume10
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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