DeustoTeka
DeustoTeka recoge la producción científica del personal docente e investigador de la Universidad de Deusto. Su propósito es reunir, archivar, preservar y aumentar la visibilidad en acceso abierto de los resultados de investigación.
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Stretching the concept of citizenship in Spain on the threshold of the 21st. century
(Universidad de Deusto = Deustuko Unibertsitatea, Instituto de Estudios Europeos, 2013-04-30) Ibarrola Armendariz, Aitor; Ruiz Vieytez, Eduardo Javier
The Spanish Constitution that was approved in 1978, after Franco's forty-year dictatorship, gave the autonomous regions freedom to implement their own policies in specific social domains. Although it would be difficult to speak of a full-fledged federal system of government, it is true that sub-state authorities have gained substantial ground in terms of organizing areas of civic life such as the health system, education, housing policies, etc. Simultaneously, traditional views on citizenship - which linked it to the Nation-State - have also been eroded "from above" as supra-national entities such as the EU, the UN, and Human Rights organizations have issued norms and regulations that have had a significant impact on our understanding of the concept. It remains unclear, though, whether these new forces shaping contemporary citizenship(s) are all pushing in the same direction.
Daño cerebral adquirido: percepción del familiar de las secuelas y su malestar psicológico.
(Colegio Oficial de la Psicología de Madrid, 2013) López de Arroyabe Castillo, Elena; Calvete Zumalde, Esther
Este estudio tuvo como objetivo evaluar la percepción que el familiar tiene de los problemas de la persona afectada por un daño cerebral adquirido y su asociación a sus propios síntomas de estrés, depresión y duelo. Participaron 223 familiares (cuidadores principales). Se desarrolló un inventario de 36 secuelas percibidas estructuradas en 6 factores: déficits cognitivos y sensoriales, cambios de personalidad, dependencia, actividad disminuida, trastornos emocionales y autoconciencia y percepción social disminuida. Los resultados mostraron que las secuelas percibidas tienen relativamente poco impacto en el malestar psicológico del familiar. Las secuelas con mayor asociación a los síntomas psicológicos fueron dependencia, asociada significativamente a sentimientos actuales de duelo, y la actividad disminuida, que se asocia a las respuestas involuntarias de estrés de aproximación y alejamiento. Estos datos contradicen la literatura que sostiene la relación causal entre secuelas percibidas y síntomas en los familiares, sugiriendo otro tipo de factores implicados.
Systemic inflammation and endothelial dysfunction influence the risk and severity of hemorrhagic transformation after endovascular treatment for acute ischemic stroke
(Frontiers Media SA, 2026) Álvarez Agoués, Kattalin; Riva Juez, Patricia de la ; Rodríguez-Antigüedad Muñoz, Jon; Gómez, Virginia; Arenaza Choperena, Gorka ; Gorostidi, Ana; Díez, Noemí; Arce Borda, Ana de ; Martínez Zabaleta, María Teresa ; Garmendia, Eñaut; Lüttich, Alex; Anabitarte González, Maier ; Larrea Peña, José Ángel; Bergareche, A; López de Munain Arregui, Adolfo ; Marta Enguita, Juan
Background – Hemorrhagic transformation (HT) is a frequent and serious complication, occurring in up to 40% of cases after endovascular treatment (EVT) for acute ischemic stroke (AIS). Inflammation has been increasingly recognized as a key factor influencing both stroke pathophysiology and post-treatment complications (such as HT) interacting with endothelial dysfunction to exacerbate vascular injury after EVT. The objective of this study is to evaluate whether systemic inflammatory status predicts HT in AIS patients, and its relationship with endothelial biomarkers in the setting of this complication. Methods – We retrospectively reviewed a prospective cohort of 229 AIS patients treated with EVT. Demographic, clinical, imaging, and laboratory data were collected. Inflammatory markers included white blood cell subsets and indices such as neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-platelet ratio (NPR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Endothelial function was assessed by flow-mediated dilation (FMD) and circulating homoarginine (HArg), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA). The main outcome was radiological or symptomatic HT, classified according to ECASS criteria. Results – HT was observed in 92 patients (40.2%), of whom 35 (36.1% of HT and 15.3% of the total) were symptomatic. In multivariate analysis, independent predictors of HT included higher NIHSS at admission, higher plasma glucose at admission, the use of non-aspiration devices, lower pre-recanalization lymphocyte count, higher pre-recanalization SII and higher NLR levels. Among endothelial function markers, HArg correlated with inflammatory markers, ANC (r = −0.2) and WBC (r = −0.19), and was associated to PH and symptomatic HT, but not with any radiologic HT after AIS. Conclusion – An altered inflammatory status prior to EVT in AIS patients is associated with an increased risk of developing HT after EVT. Additionally, endothelial dysfunction could participate in the more aggressive forms of this complication.
Supervised exercise intervention restores physical activity and MultiOMIC-Derived frailty biomarkers in older adults.
(John Wiley and Sons Inc, 2026-08-01) Marcos-Pérez, Diego; Cruces Salguero, Sara; Saeteros, Morelva; García Molina, Rafael; Ruben Alcantud-Córcoles; Alonso Bouzón, Cristina; Vergara, Itziar; Sanabria Martín, Sergio José; Rodríguez Mañas, Leocadio; Abizanda, Pedro; Matheu, Ander
Background: The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions. Recently, several transcriptomic approaches have described molecular patterns associated with frailty status. However, the effects of physical exercise interventions remain unexplored. Two studies (FRAILOMIC and BIOFRAIL) identified molecular signatures associated with frailty. The objective of the study was to analyse the expression of the FRAILOMIC and BIOFRAIL biomarkers following a multicomponent personalized exercise intervention in older adults. Methods: A multi-centre study included a control (n = 24, with 14 women and 10 men, median age 80 ± 5) and an exercise intervention group (n = 44, with 38 women and 6 men, median age 79 ± 4). The latter underwent a 16-week multicomponent presential physical exercise programme; clinical, functional and frailty assessments were performed before and after the intervention in both groups. Latent class analysis identified ‘responders’ and ‘non-responders’ to the intervention. Data in a testosterone-suppressed control cohort of older men with prostatic cancer receiving androgen deprivation therapy (n = 21) were included. Molecular biomarkers were measured via qRT-PCR and ELISA. Results: The exercise group presented improvements in functional capacity, as shown by Short Physical Performance Battery (SPPB) (post- 10.1 vs. 9.1 in pre-intervention), grip strength (18.3 vs. 16.9 kg), gait speed (0.85 vs. 0.78 m/s), sarcopenia (2.1 vs. 3.0) and frailty status by Fried Frailty Phenotype (1.6 vs 2.1 criteria) (all ≤ 0.004). ANCOVA revealed significant improvements in SPPB (p = 0.04) and grip strength (p < 0.005) with exercise. Four of the six FRAILOMIC biomarkers (miR125b, miR194, RAGE and Troponin) and six of seven BIOFRAIL biomarkers (EGR1, CXCL8, GOS2, NSF, DDX11L1 and miR454) reversed significantly their expression after exercise training (p ≤ 0.05 for FRAIOLMIC and ≤ 0.01 for BIOFRAIL respectively). In contrast, these changes were not observed in testosterone-suppressed controls, who experienced muscle loss. Latent class analysis revealed 36 ‘responders’ (with 32 cases from intervention group) and 29 ‘non-responders’. Logistic regression showed that miR454, EGR1, DDX11L1 and Troponin displayed the strongest predictive value in distinguishing responders from non-responders. Conclusions: Exercise intervention improved functional status and reversed biological frailty, as evidenced by changes in multiple MultiOMIC frailty biomarkers. Among these, the BIOFRAIL trio—miR454, EGR1 and DDX11L1—showed the strongest predictive power for intervention response with AUC of 0.83. This study provides proof-of-concept for the utility of OMIC-derived frailty biomarkers as outcome measures after intervention.
De la infancia a la adolescencia cambios en los determinantes del desplazamiento activo escolar y diario en Euskadi
(Universidade da Coruña, Servizo de Publicacións, 2026-07-01) Mateos-Marañón, Xabier; Larrinaga Undabarrena, Arkaitz; Albisua Kaperotxipi, Neritzel ; Sánchez Isla, José Ramón; Río de Frutos, Xabier
El desplazamiento activo constituye una oportunidad relevante para integrar actividad física en la vida cotidiana del alumnado; sin embargo, la evidencia disponible suele analizar sus determinantes considerando rangos de edad amplios y sin diferenciar entre distintos dominios de movilidad. El objetivo fue examinar si los determinantes sociodemográficos, socioeconómicos y territoriales del desplazamiento activo difieren entre infancia y adolescencia, y si estas asociaciones varían entre el desplazamiento activo al centro educativo y el desplazamiento activo diario. Se realizó un estudio transversal en una muestra de 1.032 escolares de 6 a 18 años de Euskadi. Se analizaron por separado dos desenlaces dicotómicos (activo/pasivo): desplazamiento activo al centro educativo y desplazamiento activo diario. Los análisis se estratificaron por etapa educativa (infancia: 6–11 años; adolescencia: 12–18 años) y se ajustaron modelos de regresión logística por sexo, índice de privación socioeconómica (MEDEA), provincia, entorno urbano, tipo de centro y práctica de deporte organizado. En la infancia, el desplazamiento activo se asoció principalmente con factores territoriales y contextuales, reflejando la influencia del entorno físico y de las condiciones locales de movilidad, con una influencia limitada de la privación socioeconómica. En la adolescencia se observó un gradiente socioeconómico consistente, especialmente en el desplazamiento activo diario, con mayores probabilidades de desplazamiento activo en niveles de privación intermedia y media-baja en comparación con el nivel más alto. Los patrones de asociación difirieron entre los dominios de desplazamiento analizados. En conclusión, los determinantes del desplazamiento activo varían según la etapa educativa y el dominio de movilidad, lo que respalda la necesidad de intervenciones específicas por etapa e incorpora una perspectiva de equidad especialmente relevante en la adolescencia.