Neuroanatomical correlates of theory of mind deficit in Parkinson's disease: a multimodal imaging study

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dc.contributor.authorDíez Cirarda, María
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorGómez Beldarrain, María Ángeles
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2026-02-18T11:05:13Z
dc.date.available2026-02-18T11:05:13Z
dc.date.issued2015-11-11
dc.date.updated2026-02-18T11:05:13Z
dc.description.abstractBackground: Parkinson's disease (PD) patients show theory of mind (ToM) deficit since the early stages of the disease, and this deficit has been associated with working memory, executive functions and quality of life impairment. To date, neuroanatomical correlates of ToM have not been assessed with magnetic resonance imaging in PD. The main objective of this study was to assess cerebral correlates of ToM deficit in PD. The second objective was to explore the relationships between ToM, working memory and executive functions, and to analyse the neural correlates of ToM, controlling for both working memory and executive functions. Methods: Thirty-seven PD patients (Hoehn and Yahr median = 2.0) and 15 healthy controls underwent a neuropsychological assessment and magnetic resonance images in a 3T-scanner were acquired. T1-weighted images were analysed with voxel-based morphometry, and white matter integrity and diffusivity measures were obtained from diffusion weighted images and analysed using tract-based spatial statistics. Results: PD patients showed impairments in ToM, working memory and executive functions; grey matter loss and white matter reduction compared to healthy controls. Grey matter volume decrease in the precentral and postcentral gyrus, middle and inferior frontal gyrus correlated with ToM deficit in PD. White matter in the superior longitudinal fasciculus (adjacent to the parietal lobe) and white matter adjacent to the frontal lobe correlated with ToM impairment in PD. After controlling for executive functions, the relationship between ToM deficit and white matter remained significant for white matter areas adjacent to the precuneus and the parietal lobe. Conclusions: Findings reinforce the existence of ToM impairment from the early Hoehn and Yahr stages in PD, and the findings suggest associations with white matter and grey matter volume decrease. This study contributes to better understand ToM deficit and its neural correlates in PD, which is a basic skill for development of healthy social relationships.en
dc.description.sponsorshipThis study was supported by the Department of Health of the Basque Government [2011111117 to NIB] and the Spanish Ministry of Economy and Competitiveness [PSI2012-32441 to NIB]en
dc.identifier.citationDíez-Cirarda, M., Ojeda, N., Peña, J., Cabrera-Zubizarreta, A., Gómez-Beldarrain, M. Á., Gómez-Esteban, J. C., & Ibarretxe-Bilbao, N. (2015). Neuroanatomical correlates of theory of mind deficit in Parkinson’s disease: a multimodal imaging study. PLoS ONE, 10(11). https://doi.org/10.1371/JOURNAL.PONE.0142234
dc.identifier.doi10.1371/JOURNAL.PONE.0142234
dc.identifier.eissn1932-6203
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5133
dc.language.isoeng
dc.publisherPublic Library of Science
dc.rights© 2015 Díez-Cirarda et al.
dc.titleNeuroanatomical correlates of theory of mind deficit in Parkinson's disease: a multimodal imaging studyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue11
oaire.citation.titlePLoS ONE
oaire.citation.volume10
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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