Multiscale kinetic model for immune reaction in coeliac disease

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dc.contributor.authorBurini, Diletta
dc.contributor.authorKnopoff, Damián Alejandro
dc.contributor.authorSerrano, Lídia
dc.date.accessioned2026-05-21T09:53:20Z
dc.date.available2026-05-21T09:53:20Z
dc.date.issued2026-04-01
dc.date.updated2026-05-21T09:53:20Z
dc.description.abstractThis paper presents a multiscale model that captures the complex dynamics of coeliac disease, a chronic T-cell-mediated autoimmune disorder triggered by gluten ingestion in genetically susceptible individuals. Grounded in the mathematical kinetic theory of active particles, the model captures the intricate dynamics of the immunological cascade that leads to small intestinal damage, involving complex interactions across molecular, cellular, and tissue scales. This approach explicitly models the different functional subsystems involved and examines the role of molecular messengers in shaping these dynamics, focusing on gluten recognition and immune system activation. Simulations demonstrate that the model can reproduce significant clinical and biological observations of coeliac disease, suggesting its potential to inform therapeutic strategies.en
dc.description.sponsorshipDamian A. Knopoff acknowledges the support by Grant PID2023-146872OB-I00-DyCMaMod funded by MICIU/AEI/10.13039.501100011033 and by Feder, EUen
dc.identifier.citationBurini, D., Knopoff, D. A., & Serrano, L. (2026). Multiscale Kinetic Model for Immune Reaction in Coeliac Disease. Mathematics, 14(8). https://doi.org/10.3390/MATH14081333
dc.identifier.doi10.3390/MATH14081333
dc.identifier.eissn2227-7390
dc.identifier.urihttps://hdl.handle.net/20.500.14454/6035
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights© 2026 by the authors
dc.subject.otherCoeliac disease
dc.subject.otherImmune competition
dc.subject.otherKinetic theory
dc.subject.otherMathematical modeling
dc.titleMultiscale kinetic model for immune reaction in coeliac diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue8
oaire.citation.titleMathematics
oaire.citation.volume14
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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