Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: a potential role of adult hippocampal neurogenesis in “curiosity”

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dc.contributor.authorMañas Padilla, María del Carmen
dc.contributor.authorMelgar Locatelli, Sonia
dc.contributor.authorVicente Holgado, Lucía
dc.contributor.authorGil Rodríguez, Sara
dc.contributor.authorRivera, Patricia
dc.contributor.authorRodríguez Pérez, Celia
dc.contributor.authorCastilla Ortega, Estela
dc.date.accessioned2025-06-19T13:07:29Z
dc.date.available2025-06-19T13:07:29Z
dc.date.issued2023-03
dc.date.updated2025-06-19T13:07:28Z
dc.description.abstractIntrinsic exploratory biases are an innate motivation for exploring certain types of stimuli or environments over others, and they may be associated with cognitive, emotional, and even personality-like traits. However, their neurobiological basis has been scarcely investigated. Considering the involvement of the hippocampus in novelty recognition and in spatial and pattern separation tasks, this work researched the role of adult hippocampal neurogenesis (AHN) in intrinsic exploratory bias for a perceptually complex object in mice. Spontaneous object preference tasks revealed that both male and female C57BL/6J mice showed a consistent unconditioned preference for exploring “complex”—irregular—objects over simpler ones. Furthermore, increasing objects’ complexity resulted in an augmented time of object exploration. In a different experiment, male mice received either vehicle or the DNA alkylating agent temozolomide (TMZ) for 4 weeks, a pharmacological treatment that reduced AHN as evidenced by immunohistochemistry. After assessment in a behavioral test battery, the TMZ-treated mice did not show any alterations in general exploratory and anxiety-like responses. However, when tested in the spontaneous object preference task, the TMZ-treated mice did not display enhanced exploration of the complex object, as evidenced both by a reduced exploration time—specifically for the complex object—and a lack of preference for the complex object over the simple one. This study supports a novel role of AHN in intrinsic exploratory bias for perceptual complexity. Moreover, the spontaneous complex object preference task as a rodent model of “curiosity” is discussed.en
dc.description.sponsorshipMCIN/AEI/10.13039/501100011033,Grant/Award Number:PID2020-114374RB-I00; National System ofHealth, EU-ERDF-ISCIII, Grant/AwardNumber: CP19/00068; Spanish Ministry ofScience, Innovation and Universities,Grant/Award Numbers: FPU17/00276,FPU18/00941en
dc.identifier.citationMañas-Padilla, M. C., Melgar-Locatelli, S., Vicente, L., Gil-Rodríguez, S., Rivera, P., Rodríguez-Pérez, C., & Castilla-Ortega, E. (2023). Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: a potential role of adult hippocampal neurogenesis in “curiosity”. Journal of Comparative Neurology, 531(4), 548-560. https://doi.org/10.1002/CNE.25442
dc.identifier.doi10.1002/CNE.25442
dc.identifier.eissn1096-9861
dc.identifier.issn0021-9967
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3102
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.rights© 2022 The Authors
dc.subject.otherAnhedonia
dc.subject.otherChemotherapy
dc.subject.otherFemale mice
dc.subject.otherIntrinsic exploratory bias
dc.subject.otherNovelty
dc.titleTemozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: a potential role of adult hippocampal neurogenesis in “curiosity”en
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage560
oaire.citation.issue4
oaire.citation.startPage548
oaire.citation.titleJournal of Comparative Neurology
oaire.citation.volume531
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc/4.0/
oaire.versionVoR
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