Intelligence quotient changes over 10 years: diversity of cognitive profiles in first episode of psychosis and healthy controls

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dc.contributor.authorMurillo García, Nancy
dc.contributor.authorOrtiz García de la Foz, Víctor
dc.contributor.authorMiguel-Corredera, Margarita
dc.contributor.authorVázquez Bourgon, Javier
dc.contributor.authorSetién Suero, Esther
dc.contributor.authorNeergaard, Karl
dc.contributor.authorMoya Higueras, Jorge
dc.contributor.authorCrespo Facorro, Benedicto
dc.contributor.authorAyesa Arriola, Rosa
dc.date.accessioned2025-07-09T11:45:17Z
dc.date.available2025-07-09T11:45:17Z
dc.date.issued2023-04
dc.date.updated2025-07-09T11:45:17Z
dc.description.abstractObjective: This study aimed to analyse whether intelligence quotient (IQ) improves, declines, or remains stable over 10 years among FEP patients and healthy subjects. Methods: A group of FEP patients enrolled in a Program of First Episode Psychosis in Spain called PAFIP, and a sample of Healthy Controls (HC) completed the same neuropsychological battery at baseline and approximately 10 years later, which included the WAIS vocabulary subtest to estimate premorbid IQ and 10-year IQ. Cluster analysis was performed separately in the patient group and the HC group to determine their profiles of intellectual change. Results: One hundred and thirty-seven FEP patients were grouped into five clusters: “Improved low IQ” (9.49 % of patients), “Improved average IQ” (14.6 %), “Preserved low IQ” (17.52 %), “Preserved average IQ” (43.06 %), and “Preserved high IQ” (15.33 %). Ninety HC were grouped into three clusters: “Preserved low IQ” (32.22 % of the HC), “Preserved average IQ” (44.44 %), and “Preserved high IQ” (23.33 %). The first two clusters of FEP patients, characterized by a low IQ, earlier age at illness onset, and lower educational attainment, showed a substantial cognitive improvement. The remaining clusters demonstrated cognitive stability. Conclusions: The FEP patients showed intellectual improvement or stability, but no decline post-onset of psychosis. However, their profiles of intellectual change are more heterogeneous than that of HC over 10 years. Particularly, there is a subgroup of FEP patients with a significant potential for long-term cognitive enhancement.en
dc.description.sponsorshipThis work was supported by a Miguel Servet contract (Dr. Rosa Ayesa-Arriola) from the Carlos III Health Institute (CP18/00003); a “Juan de la Cierva-Formacion´ ” contract (Dr. Esther Seti´en-Suero) from the Spanish Ministry of Science and Innovation (FJC2019-042390-I/AEI/10.13039/501100011033); and a predoctoral contract (Nancy Murillo-Garcia) from the Valdecilla Biomedical Research Institute and the University of Cantabria (BOC49, REF. IDI-13)en
dc.identifier.citationMurillo-García, N., Ortíz-García de la Foz, V., Miguel-Corredera, M., Vázquez-Bourgon, J., Setién-Suero, E., Neergaard, K., Moya-Higueras, J., Crespo-Facorro, B., & Ayesa-Arriola, R. (2023). Intelligence quotient changes over 10 years: diversity of cognitive profiles in first episode of psychosis and healthy controls. Schizophrenia Research, 254, 163-172. https://doi.org/10.1016/J.SCHRES.2023.02.025
dc.identifier.doi10.1016/J.SCHRES.2023.02.025
dc.identifier.eissn1573-2509
dc.identifier.issn0920-9964
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3183
dc.language.isoeng
dc.publisherElsevier B.V.
dc.rights© 2023 The Authors
dc.subject.otherIntelligence
dc.subject.otherLongitudinal
dc.subject.otherNeurocognition
dc.subject.otherSchizophrenia spectrum disorders
dc.titleIntelligence quotient changes over 10 years: diversity of cognitive profiles in first episode of psychosis and healthy controlsen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage172
oaire.citation.startPage163
oaire.citation.titleSchizophrenia Research
oaire.citation.volume254
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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