Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in Catalonia: characteristics and natural history

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dc.contributor.authorBrunet Mas, Eduard
dc.contributor.authorSelva, Anna
dc.contributor.authorBas Cutrina, Francesc
dc.contributor.authorBrujats, Anna
dc.contributor.authorCaballol Oliva, Berta
dc.contributor.authorFont Marimon, Rebeca
dc.contributor.authorGómez Pastrana, Bàrbara
dc.contributor.authorGonzalez Muñosa, Carlos
dc.contributor.authorBusquets Casals, David
dc.contributor.authorMonfort, David
dc.contributor.authorVera, Diana Patrícia
dc.contributor.authorMaristany, Elisabet
dc.contributor.authorCirera, Gemma
dc.contributor.authorTorres Vicente, Gisela
dc.contributor.authorCastro Poceiro, Jesús
dc.contributor.authorLópez, Joel
dc.contributor.authorGonzález González, Laura
dc.contributor.authorMàrquez Mosquera, Lucia
dc.contributor.authorGallach Montero, Marta
dc.contributor.authorEsteve Comas, María
dc.contributor.authorTremosa, Gemma
dc.contributor.authorTorra Alsina, Sandra
dc.contributor.authorRobles Alonso, Virginia
dc.contributor.authorGarcía Iglesias, Pilar
dc.contributor.authorRodríguez Lago, Iago
dc.contributor.authorCalvet Calvo, Xavier
dc.date.accessioned2025-06-04T07:53:56Z
dc.date.available2025-06-04T07:53:56Z
dc.date.issued2024-12-26
dc.date.updated2025-06-04T07:53:55Z
dc.description.abstractINTRODUCTION: Inflammatory bowel disease (IBD) is usually diagnosed when symptomatic. Prognosis and evolution of preclinical IBD is largely unknown. However, colorectal cancer screening programs (CRCSP) detect a subset of patients with IBD with no symptoms. The aim of this study was to describe the natural history of asymptomatic IBD diagnosed through CRCSP. METHODS: An observational, longitudinal, and retrospective study was performed at 22 centers in Catalonia between January 2010 and December 2019 including patients with asymptomatic IBD detected in the CRCSP. Demographic data and IBD characteristics, evolution, and treatment were recorded. Descriptive statistics and Kaplan-Meier analysis were used for the analysis. Data were given separately for IBD, Crohn’s disease (CD), ulcerative colitis (UC), and IBD unclassified (IBDU). RESULTS: One hundred eighty-eight patients were included: 103 UC (54.8%), 60 CD (31.9%), and 25 IBDU (13.3%). Sixty-six (35.1%) were women, and the average age was 59.9 6 5.9 years. Sixty-four patients (34.0%) developed symptoms after a median follow-up of 35.6 months. Diarrhea was the most frequent symptom for CD and IBDU (25.4% and 11.5%, respectively) and blood in stools for UC (21.4%). The median time to first symptom was 11.6 months. Treatment was prescribed in 135 patients (72.2%); mesalazine was the most prescribed drug (123 patients; 65.4%). Thirteen patients (6.9%) required biological treatment. None underwent surgery. DISCUSSION: Around one-third of asymptomatic patients with IBD developed symptoms after a medium follow-up of 3 years. Only 6.9% required biological treatment, and none required surgery. Overall, prognosis of asymptomatic IBD seems better.en
dc.description.sponsorshipThis study received a 6,000V grant for initiation to research from the Societat Catalana de Digestologiaen
dc.identifier.citationBrunet-Mas, E., Selva, A., Bas-Cutrina, F., Brujats, A., Caballol, B., Font, R., Gómez, B., Gonzalez-Muñosa, C., Busquets, D., Monfort, D., Patrícia Vera, D., Maristany, E., Cirera, G., Torres, G., Castro-Poceiro, J., Lopez, J., Gonzalez-Gonzalez, L., Màrquez-Mosquera, L., Gallach, M., et al. (2024). Asymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in Catalonia: characteristics and natural history. Clinical and Translational Gastroenterology, 16(2). https://doi.org/10.14309/CTG.0000000000000740
dc.identifier.doi10.14309/CTG.0000000000000740
dc.identifier.issn2155-384X
dc.identifier.urihttps://hdl.handle.net/20.500.14454/2928
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.rights© 2024 The Author(s)
dc.subject.otherAsymptomatic
dc.subject.otherCrohn’s disease
dc.subject.otherInflammatory bowel disease
dc.subject.otherScreening
dc.subject.otherUlcerative colitis
dc.titleAsymptomatic inflammatory bowel disease diagnosed during colorectal cancer population screening in Catalonia: characteristics and natural historyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue2
oaire.citation.titleClinical and Translational Gastroenterology
oaire.citation.volume16
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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