Brain network interactions in transgender individuals with gender incongruence

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dc.contributor.authorUribe, Carme
dc.contributor.authorJunqué i Plaja, Carme
dc.contributor.authorGómez Gil, Esther
dc.contributor.authorAbos Ortega, Alexandra
dc.contributor.authorMueller, Sven C.
dc.contributor.authorGuillamon, Antonio
dc.date.accessioned2025-11-10T11:06:23Z
dc.date.available2025-11-10T11:06:23Z
dc.date.issued2020-02-10
dc.date.updated2025-11-10T11:06:23Z
dc.description.abstractFunctional brain organization in transgender persons remains unclear. Our aims were to investigate global and regional connectivity differences within functional networks in transwomen and transmen with early-in-life onset gender incongruence; and to test the consistency of two available hypotheses that attempted to explain gender variants: (i) a neurodevelopmental cortical hypothesis that suggests the existence of different brain phenotypes based on structural MRI data and genes polymorphisms of sex hormone receptors; (ii) a functional-based hypothesis in relation to regions involved in the own body perception. T2*-weighted images in a 3-T MRI were obtained from 29 transmen and 17 transwomen as well as 22 cisgender women and 19 cisgender men. Resting-state independent component analysis, seed-to-seed functional network and graph theory analyses were performed. Transmen, transwomen, and cisgender women had decreased connectivity compared with cisgender men in superior parietal regions, as part of the salience (SN) and the executive control (ECN) networks. Transmen also had weaker connectivity compared with cisgender men between intra-SN regions and weaker inter-network connectivity between regions of the SN, the default mode network (DMN), the ECN and the sensorimotor network. Transwomen had lower small-worldness, modularity and clustering coefficient than cisgender men. There were no differences among transmen, transwomen, and ciswomen. Together these results underline the importance of the SN interacting with DMN, ECN, and sensorimotor networks in transmen, involving regions of the entire brain with a frontal predominance. Reduced global connectivity graph-theoretical measures were a characteristic of transwomen. It is proposed that the interaction between networks is a keystone in building a gendered self. Finally, our findings suggest that both proposed hypotheses are complementary in explaining brain differences between gender variants.en
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Science and Innovation [grant numbers PSI2014-58004-P and PGC2018-094919-B-C21] to AG. CU was supported by a fellowship from 2014, Spanish Ministry of Economy and Competitiveness [grant number BES-2014-068173] and is co-financed by the European Social Fund (ESF) and AA by a 2016 fellowship from the Departament d’Empresa i Coneixement de la Generalitat de Catalunya, Agència de Gestió d’Ajuts Universitaris i de Recerca [grant number AGAUR; 2016FI_B 00360]en
dc.identifier.citationUribe, C., Junque, C., Gómez-Gil, E., Abos, A., Mueller, S. C., & Guillamon, A. (2020). Brain network interactions in transgender individuals with gender incongruence. NeuroImage, 211. https://doi.org/10.1016/J.NEUROIMAGE.2020.116613
dc.identifier.doi10.1016/J.NEUROIMAGE.2020.116613
dc.identifier.eissn1095-9572
dc.identifier.issn1053-8119
dc.identifier.urihttps://hdl.handle.net/20.500.14454/4325
dc.language.isoeng
dc.publisherAcademic Press Inc.
dc.rights© 2020 The Authors
dc.subject.otherConnectivity
dc.subject.otherfMRI
dc.subject.otherGender incongruence
dc.subject.otherGraph theory
dc.subject.otherTransmen
dc.subject.otherTranswomen
dc.titleBrain network interactions in transgender individuals with gender incongruenceen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.titleNeuroImage
oaire.citation.volume211
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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