Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's disease

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dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorDíez Cirarda, María
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGómez Beldarrain, María Ángeles
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2026-03-11T12:40:23Z
dc.date.available2026-03-11T12:40:23Z
dc.date.issued2016-12
dc.date.updated2026-03-11T12:40:23Z
dc.description.abstractObjective To assess whether functional neural connectivity is disrupted between the regions of the default mode network (DMN) in Parkinson's disease (PD) and how this connectivity is related to cognition, brain gray matter structure and white matter integrity and diffusivity. Methods Thirty-seven PD patients and 16 healthy controls were evaluated, using resting-state functional magnetic resonance imaging (MRI), T1-weighted MRI, diffusion-weighted imaging and a battery of cognitive tests. Functional connectivity between the regions of the DMN, specifically in the precuneus, anterior and posterior cingulate, medial prefrontal and temporal and inferior parietal cortices was assessed with seed-to-voxel connectivity; gray matter volume and white matter values were determined using voxel-based morphometry and tract-based spatial statistics. Results Reduced functional connectivity was observed between the posterior cingulate and medial temporal lobe in PD. Lower cognitive performance, gray matter loss in posterior, medial temporal and parietal areas, and fractional anisotropy reduction in the white matter adjacent to DMN regions were also observed in PD patients compared with healthy controls. Lower DMN functional connectivity correlated with lower verbal and visual memory and visual abilities performance in PD. In addition, lower DMN functional connectivity correlated with lower gray matter volume in the posterior cingulate and precuneus, and with lower white matter fractional anisotropy of the inferior longitudinal and posterior cingulate fasciculi in PD. Conclusions By combining different neuroimaging techniques and cognitive data, results showed that functional connectivity alteration between the regions of the DMN is associated with lower cognitive performance and gray and white matter abnormalities in PD.en
dc.description.sponsorshipThis study was supported by the Health Department of the Basque Government (2011111117; to Dr. Naroa Ibarretxe Bilbao) and the Spanish Ministry of Economy and Competitiveness (PSI2012-32441; to Dr. Naroa Ibarretxe Bilbao)en
dc.identifier.citationLucas-Jiménez, O., Ojeda, N., Peña, J., Díez-Cirarda, M., Cabrera-Zubizarreta, A., Gómez-Esteban, J. C., Gómez-Beldarrain, M. Á., & Ibarretxe-Bilbao, N. (2016). Altered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson’s disease. Parkinsonism and Related Disorders, 33, 58-64. https://doi.org/10.1016/J.PARKRELDIS.2016.09.012
dc.identifier.doi10.1016/J.PARKRELDIS.2016.09.012
dc.identifier.eissn1873-5126
dc.identifier.issn1353-8020
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5419
dc.language.isoeng
dc.publisherElsevier Ltd
dc.rights© 2016 The Authors
dc.subject.otherCognitive impairment
dc.subject.otherDefault mode network
dc.subject.otherDiffusion-weighted imaging
dc.subject.otherFunctional connectivity
dc.subject.otherGray matter
dc.subject.otherParkinson's disease
dc.titleAltered functional connectivity in the default mode network is associated with cognitive impairment and brain anatomical changes in Parkinson's diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage64
oaire.citation.startPage58
oaire.citation.titleParkinsonism and Related Disorders
oaire.citation.volume33
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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