Integrative group-based cognitive rehabilitation efficacy in multiple sclerosis: a randomized clinical trial

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dc.contributor.authorRilo Cano, Oiane
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorRodríguez-Antigüedad Zarranz, Alfredo
dc.contributor.authorMendibe Bilbao, María del Mar
dc.contributor.authorGómez Gastiasoro, Ainara
dc.contributor.authorDeluca, John
dc.contributor.authorChiaravalloti, Nancy
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2026-03-02T11:42:58Z
dc.date.available2026-03-02T11:42:58Z
dc.date.issued2018-01-16
dc.date.updated2026-03-02T11:42:58Z
dc.description.abstractPurpose: This study aimed to determine the efficacy of the integrative group-based cognitive rehabilitation programme, REHACOP, on improving cognitive functions in multiple sclerosis (MS). Methods: Fourty-two MS patients were randomized to the treatment programme REHACOP (n = 21) or waiting list control condition (n = 21). The REHACOP group received cognitive rehabilitation in group format for three months focused on attention, processing speed, learning and memory, language, executive functioning, and social cognition. Patients completed a neuropsychological assessment at baseline and follow-up, which included tests of attention, processing speed, working memory, verbal memory, verbal fluency, and executive functioning. Repeated measures multivariate analysis of covariance (MANCOVA) was used to determine the efficacy of the cognitive rehabilitation programme. Results: Group × Time interactions revealed significant improvements in the REHACOP group as compared with the control group for processing speed (p = 0.011, np 2 = 0.16), working memory (p = 0.014, np 2 = 0.15), verbal memory (p = 0.025, np 2 = 0.13), and executive functioning (p = 0.024, np 2 = 0.13), showing medium–large effect sizes. Conclusions: Patients receiving REHACOP showed improvements in several cognitive domains. This preliminary study thus provides evidence supporting the efficacy of this integrative group-based cognitive rehabilitation intervention in MS. Future research should confirm these findings, examine the impact of the treatment on everyday life functioning and explore the presence of brain changes associated with cognitive rehabilitation.Implications for rehabilitation This study provides initial evidence for integrative group-based cognitive rehabilitation efficacy in MS patients through the implementation of the REHACOP cognitive rehabilitation programme. Patients received cognitive rehabilitation for three months (3 one-hour-sessions per week) focused on training attention, learning and memory, language, executive functioning, and social cognition. Patients attending REHACOP sessions showed medium to large and statistically significant improvements in processing speed, working memory, verbal memory, and executive functioning.en
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness [grant number PSI2012-32441 to N.I.B.]en
dc.identifier.citationRilo, O., Peña, J., Ojeda, N., Rodríguez-Antigüedad, A., Mendibe-Bilbao, M., Gómez-Gastiasoro, A., DeLuca, J., Chiaravalloti, N., & Ibarretxe-Bilbao, N. (2018). Integrative group-based cognitive rehabilitation efficacy in multiple sclerosis: a randomized clinical trial. Disability and Rehabilitation, 40(2), 208-216. https://doi.org/10.1080/09638288.2016.1250168
dc.identifier.doi10.1080/09638288.2016.1250168
dc.identifier.eissn1464-5165
dc.identifier.issn0963-8288
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5296
dc.language.isoeng
dc.publisherTaylor and Francis Ltd
dc.rights© 2016 The Author(s)
dc.subject.otherREHACOP
dc.subject.otherNeuropsychological rehabilitation
dc.subject.otherCognition
dc.subject.otherNeurodegenerative diseases
dc.subject.otherMultiple sclerosis
dc.titleIntegrative group-based cognitive rehabilitation efficacy in multiple sclerosis: a randomized clinical trialen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage216
oaire.citation.issue2
oaire.citation.startPage208
oaire.citation.titleDisability and Rehabilitation
oaire.citation.volume40
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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