Neuromelanin contrast optimization and improved visualization of the substantia nigra in a 3D gradient-echo sequence with magnetization transfer

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dc.contributor.authorGarate Andikoetxea, Begoña
dc.contributor.authorMartín Bastida, Antonio
dc.contributor.authorVidorreta, Marta
dc.contributor.authorRodríguez Oroz, María Cruz
dc.contributor.authorSoustelle, Lucas
dc.contributor.authorTroalen, Thomas
dc.contributor.authorFernández Seara, María Asunción
dc.date.accessioned2025-09-26T10:57:06Z
dc.date.available2025-09-26T10:57:06Z
dc.date.issued2025-08-19
dc.date.updated2025-09-26T10:57:06Z
dc.description.abstractNeuromelanin (NM) magnetic resonance imaging has been used to evaluate the loss of melanized neurons in the substantia nigra, the main characteristic of Parkinson disease, typically by measuring the contrast ratio (CR) between the NM-rich areas and the cerebral peduncles in the midbrain. Neuromelanin contrast can be generated by employing a 3D gradient-echo (GRE) sequence with magnetization transfer (MT). In this work, we first evaluated the effect of the MT pulse frequency on the CR and contrast-to-noise ratio (CNR), analyzing a large frequency range from 500 to 100K Hz. Secondly, the impact of the 3D GRE sequence flip angle (FA) was evaluated using angles from 5° to 40°. Additionally, images were acquired both with and without MT for each FA, providing an opportunity to examine the effect of MT on tissue proton density, T1, and T2* values. Results showed that the highest CR and CNR were obtained for the lower MT frequencies (500–2000 Hz) and lower FAs (5°–10°). The lower FAs improved the visualization of the neuromelanin-rich area in the substantia nigra and facilitated delineating its volume. In addition, this work showed that the MT pulse decreased the T1 and PD of the tissue. Furthermore, simulations supported the obtained in vivo results.en
dc.description.sponsorshipThis work was supported by Siemens Healthineersen
dc.identifier.citationAndikoetxea, B., Martín-Bastida, A., Vidorreta, M., Rodríguez-Oroz, M., Soustelle, L., Troalen, T., & Fernández-Seara, Maria A. (2025). Neuromelanin contrast optimization and improved visualization of the substantia nigra in a 3D gradient-echo sequence with magnetization transfer. NMR in Biomedicine, 38(9). https://doi.org/10.1002/NBM.70123
dc.identifier.doi10.1002/NBM.70123
dc.identifier.eissn1099-1492
dc.identifier.issn0952-3480
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3761
dc.language.isoeng
dc.publisherJohn Wiley and Sons Ltd
dc.rights© 2025 The Author(s)
dc.subject.otherGRE
dc.subject.otherMagnetization transfer
dc.subject.otherNeuromelanin
dc.subject.otherSubstantia nigra
dc.subject.otherT1
dc.subject.otherTissue properties
dc.titleNeuromelanin contrast optimization and improved visualization of the substantia nigra in a 3D gradient-echo sequence with magnetization transferen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue9
oaire.citation.titleNMR in Biomedicine
oaire.citation.volume38
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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