Recent advances and potential multi-omics approaches in the early phases of inflammatory bowel disease

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dc.contributor.authorRodríguez Lago, Iago
dc.contributor.authorBlackwell, Jonathan
dc.contributor.authorMateos Andrés, Beatriz
dc.contributor.authorMartínez Marigorta, Urko
dc.contributor.authorBarreiro de Acosta, Manuel
dc.contributor.authorPollok, Richard
dc.date.accessioned2025-09-02T15:43:49Z
dc.date.available2025-09-02T15:43:49Z
dc.date.issued2023-05-11
dc.date.updated2025-09-02T15:43:49Z
dc.description.abstractInflammatory bowel disease leads to debilitating gastrointestinal symptoms and reduced quality of life, resulting in a significant burden on healthcare utilization and costs. Despite substantial advancements in diagnosis and treatment, there may still be considerable delays in diagnosing some patients. To reduce disease progression before the full disease spectrum appears and improve prognostic outcomes, several strategies have concentrated on early intervention and prevention. Recent evidence shows that initial immune response changes and endoscopic lesions may exist for years before diagnosis, implying the existence of a preclinical phase of inflammatory bowel disease comparable to findings in other immune-mediated disorders. In this review, we highlight the most relevant findings regarding preclinical inflammatory bowel disease and the prospective role of novel omics techniques in this field.en
dc.description.sponsorshipI.R.-L. is supported by a research grant from Gobierno Vasco—Eusko Jaurlaritza [Grant No 2020222004] and by Biobizkaia HRI [Grant No BCB/I/LIB/22/008]. Beatriz Mateos is supported by “Opportunity To Talent” grant from ONCE Foundation. Urko M. Marigorta thanks the Spanish Ministry of Science MCIN/AEI/10.13039/501100011033 (PID2019-108244RA-I00, RYC2020-030632-I, CEX2021-001136-S) and the ”la Caixa” Foundation (ID 100010434, fellowship No LCF/BQ/LI18/11630001)en
dc.identifier.citationRodríguez-Lago, I., Blackwell, J., Mateos, B., Marigorta, U. M., Barreiro-de Acosta, M., & Pollok, R. (2023). Recent advances and potential multi-omics approaches in the early phases of inflammatory bowel disease. Journal of Clinical Medicine, 12(10). https://doi.org/10.3390/JCM12103418
dc.identifier.doi10.3390/JCM12103418
dc.identifier.eissn2077-0383
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3454
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2023 by the authors
dc.subject.otherCrohn’s disease
dc.subject.otherDiagnosis
dc.subject.otherEarly
dc.subject.otherPreclinical
dc.subject.otherUlcerative colitis
dc.titleRecent advances and potential multi-omics approaches in the early phases of inflammatory bowel diseaseen
dc.typereview article
dcterms.accessRightsopen access
oaire.citation.issue10
oaire.citation.titleJournal of Clinical Medicine
oaire.citation.volume12
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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