Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial

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dc.contributor.authorDíez Cirarda, María
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGómez Beldarrain, María Ángeles
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2026-01-15T12:12:40Z
dc.date.available2026-01-15T12:12:40Z
dc.date.issued2017
dc.date.updated2026-01-15T12:12:40Z
dc.description.abstractCognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson’s disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy). T1-weighted, diffusion weighted and functional magnetic resonance images (fMRI) during resting-state and during a memory paradigm (with learning and recognition tasks) were acquired at pre-treatment and post-treatment. Cerebral changes were assessed with repeated measures ANOVA 2 × 2 for group x time interaction. During resting-state fMRI, the REHACOP group showed significantly increased brain connectivity between the left inferior temporal lobe and the bilateral dorsolateral prefrontal cortex compared to the control group. Moreover, during the recognition fMRI task, the REHACOP group showed significantly increased brain activation in the left middle temporal area compared to the control group. During the learning fMRI task, the REHACOP group showed increased brain activation in the left inferior frontal lobe at post-treatment compared to pre-treatment. No significant structural changes were found between pre- and post-treatment. Finally, the REHACOP group showed significant and positive correlations between the brain connectivity and activation and the cognitive performance at post-treatment. This randomized controlled trial suggests that an integrative cognitive rehabilitation program can produce significant functional cerebral changes in PD patients and adds evidence to the efficacy of cognitive rehabilitation programs in the therapeutic approach for PD.en
dc.description.sponsorshipThis study was supported by the Department of Health of the Basque Government [2011111117 to Dr. Naroa Ibarretxe-Bilbao] and the Spanish Ministry of Economy and Competitiveness [PSI2012–32441 to Dr. Naroa Ibarretxe-Bilbao]en
dc.identifier.citationDíez-Cirarda, M., Ojeda, N., Peña, J., Cabrera-Zubizarreta, A., Lucas-Jiménez, O., Gómez-Esteban, J. C., Gómez-Beldarrain, M. Á., & Ibarretxe-Bilbao, N. (2017). Increased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trial. Brain Imaging and Behavior, 11(6), 1640-1651. https://doi.org/10.1007/S11682-016-9639-X
dc.identifier.doi10.1007/S11682-016-9639-X
dc.identifier.eissn1931-7565
dc.identifier.issn1931-7557
dc.identifier.urihttps://hdl.handle.net/20.500.14454/4716
dc.language.isoeng
dc.publisherSpringer New York LLC
dc.rights© The Author(s) 2016
dc.subject.otherBrain activation
dc.subject.otherBrain connectivity
dc.subject.otherCerebral changes
dc.subject.otherParkinson’s disease
dc.subject.otherPlasticity
dc.subject.otherRandomized controlled trial
dc.titleIncreased brain connectivity and activation after cognitive rehabilitation in Parkinson’s disease: a randomized controlled trialen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage1651
oaire.citation.issue6
oaire.citation.startPage1640
oaire.citation.titleBrain Imaging and Behavior
oaire.citation.volume11
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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