Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice

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dc.contributor.authorMañas Padilla, María del Carmen
dc.contributor.authorTezanos, Patricia
dc.contributor.authorCintado, Elisa
dc.contributor.authorVicente Holgado, Lucía
dc.contributor.authorSánchez Salido, Lourdes
dc.contributor.authorGil Rodríguez, Sara
dc.contributor.authorTrejo, Jose Luis
dc.contributor.authorSantín Núñez, Luis Javier
dc.contributor.authorCastilla Ortega, Estela
dc.date.accessioned2025-07-29T11:34:58Z
dc.date.available2025-07-29T11:34:58Z
dc.date.issued2023-01
dc.date.updated2025-07-29T11:34:58Z
dc.description.abstractCocaine is a widely used psychostimulant drug whose repeated exposure induces persistent cognitive/emotional dysregulation, which could be a predictor of relapse in users. However, there is scarce evidence on effective treatments to alleviate these symptoms. Environmental enrichment (EE) has been shown to be associated with improved synaptic function and cellular plasticity changes related to adult hippocampal neurogenesis (AHN), resulting in cognitive enhancement. Therefore, EE could mitigate the negative impact of chronic administration of cocaine in mice and reduce the emotional and cognitive symptoms present during cocaine abstinence. In this study, mice were chronically administered with cocaine for 14 days, and control mice received saline. After the last cocaine or saline dose, mice were submitted to control or EE housing conditions, and they stayed undisturbed for 28 days. Subsequently, mice were evaluated with a battery of behavioural tests for exploratory activity, emotional behaviour, and cognitive performance. EE attenuated hyperlocomotion, induced anxiolytic-like behaviour and alleviated cognitive impairment in spatial memory in the cocaine-abstinent mice. The EE protocol notably upregulated AHN in both control and cocaine-treated mice, though cocaine slightly reduced the number of immature neurons. Altogether, these results demonstrate that EE could enhance hippocampal neuroplasticity ameliorating the behavioural and cognitive consequences of repeated administration of cocaine. Therefore, environmental stimulation may be a useful strategy in the treatment cocaine addiction.en
dc.description.sponsorshipMINECO-AEI, Grant/Award Numbers:PSI2015-73,156-JIN, PSI2017-82604R;MICINN, Grant/Award Number:PID2020-113806RB-I00; MCIN/AEI/10.13039/501100011033, Grant/AwardNumber: PID2020-114374RB-I00; Universityof Malaga; Spanish Ministry of Science, Innovation and Universities, Grant/AwardNumbers: FPU17/00276, FPU18/00069,FPU18/00941en
dc.identifier.citationMañas-Padilla, M. C., Tezanos, P., Cintado, E., Vicente, L., Sánchez-Salido, L., Gil-Rodríguez, S., Trejo, J. L., Santín, L. J., & Castilla-Ortega, E. (2023). Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice. Addiction Biology, 28(1). https://doi.org/10.1111/ADB.13244
dc.identifier.doi10.1111/ADB.13244
dc.identifier.eissn1369-1600
dc.identifier.issn1355-6215
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3303
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.rights© 2022 The Authors
dc.subject.otherAdult hippocampal neurogenesis
dc.subject.otherCocaine use
dc.subject.otherCognitive impairment
dc.subject.otherEnvironmental enrichment
dc.titleEnvironmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn miceen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue1
oaire.citation.titleAddiction Biology
oaire.citation.volume28
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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