Early interpersonal trauma reduces temporoparietal junction activity during spontaneous mentalising

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dc.contributor.authorCracco, Emiel
dc.contributor.authorHudson, Anna R.
dc.contributor.authorVan Hamme, Charlotte
dc.contributor.authorMaeyens, Lien
dc.contributor.authorBrass, Marcel
dc.contributor.authorMueller, Sven C.
dc.date.accessioned2026-02-09T13:34:32Z
dc.date.available2026-02-09T13:34:32Z
dc.date.issued2020-04-04
dc.date.updated2026-02-09T13:34:32Z
dc.description.abstractExperience of interpersonal trauma and violence alters self-other distinction and mentalising abilities (also known as theory of mind, or ToM), yet little is known about their neural correlates. This fMRI study assessed temporoparietal junction (TPJ) activation, an area strongly implicated in interpersonal processing, during spontaneous mentalising in 35 adult women with histories of childhood physical, sexual, and/or emotional abuse (childhood abuse; CA) and 31 women without such experiences (unaffected comparisons; UC). Participants watched movies during which an agent formed true or false beliefs about the location of a ball, while participants always knew the true location of the ball. As hypothesised, right TPJ activation was greater for UCs compared to CAs for false vs true belief conditions. In addition, CAs showed increased functional connectivity relative to UCs between the rTPJ and dorsomedial prefrontal cortex. Finally, the agent's belief about the presence of the ball influenced participants' responses (ToM index), but without group differences. These findings highlight that experiencing early interpersonal trauma can alter brain areas involved in the neural processing of ToM and perspective-taking during adulthood.en
dc.description.sponsorshipThis work was supported by a 2–4-year grant (01J05415) from the Special Research Fund (BOF) at Ghent University to S.C.M. and M.B. E.C. was also supported by the Research Foundations Flanders (FWO18/PDO/049).en
dc.identifier.citationCracco, E., Hudson, A. R., Van Hamme, C., Maeyens, L., Brass, M., & Mueller, S. C. (2020). Early interpersonal trauma reduces temporoparietal junction activity during spontaneous mentalising. Social Cognitive and Affective Neuroscience, 15(1), 12-22. https://doi.org/10.1093/SCAN/NSAA015
dc.identifier.doi10.1093/SCAN/NSAA015
dc.identifier.eissn1749-5024
dc.identifier.issn1749-5016
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5054
dc.language.isoeng
dc.publisherOxford University Press
dc.rights© The Author(s) 2020. Published by Oxford University Press
dc.subject.otherChildhood abuse
dc.subject.otherMentalising
dc.subject.otherTemporoparietal junction (TPJ)
dc.subject.otherTheory of mind (ToM)
dc.subject.otherTrauma
dc.titleEarly interpersonal trauma reduces temporoparietal junction activity during spontaneous mentalisingen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage22
oaire.citation.issue1
oaire.citation.startPage12
oaire.citation.titleSocial Cognitive and Affective Neuroscience
oaire.citation.volume15
oaire.licenseConditionttps://creativecommons.org/licenses/by-nc/4.0/
oaire.versionVoR
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