Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients

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dc.contributor.authorGómez Beldarrain, María Ángeles
dc.contributor.authorOroz, Isabel
dc.contributor.authorGarcía-Zapirain, Begoña
dc.contributor.authorFernandez-Ruanova, Begoña
dc.contributor.authorGarcía Fernández, Yolanda
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorAntón Ladislao, Ane
dc.contributor.authorAguirre Larracoechea, Urko
dc.contributor.authorGarcía-Moncó Carra, Juan Carlos
dc.date.accessioned2026-02-23T09:21:00Z
dc.date.available2026-02-23T09:21:00Z
dc.date.issued2016-02-01
dc.date.updated2026-02-23T09:21:00Z
dc.description.abstractBackground: Structural white matter abnormalities in pain-modulating, regions are present in migraine. Whether they are associated with pain chronification and with cognitive reserve is unclear. Methods: Prospective, cohort, six-month study of adult patients with episodic or chronic migraine, and controls. Cognitive reserve, quality of life, impact of pain on daily living, depression and anxiety were assessed. Participants underwent a diffusion-tensor MRI to establish the integrity of white matter tracts of three regions of interest (ROIs) implicated in pain modulation, emotion, cognition and resilience (anterior insula, anterior cingulate gyrus, and uncinate fasciculus). Results: Fifty-two individuals were enrolled: 19 episodic migraine patients, 18 chronic migraine patients, and 15 controls. The analysis of the fractional anisotropy in the ROIs showed that those patients with the poorest prognosis (i.e., those with chronic migraine despite therapy at six months -long-term chronic migraneurs) had a significantly lower fractional anisotropy in the right ROIs. Participants with higher cognitive reserve also had greater fractional anisotropy in the right anterior insula and both cingulate gyri. Multivariate analysis showed a significant association between cognitive reserve, migraine frequency, and fractional anisotropy in the right-sided regions of interest. Conclusions: Long-term chronic migraine patients show abnormalities in anterior white matter tracts, particularly of the right hemisphere, involved in pain modulation emotion, cognition and resilience. Robustness in these areas is associated with a higher cognitive reserve, which in turn might result in a lower tendency to migraine chronification.en
dc.identifier.citationGomez-Beldarrain, M., Oroz, I., Zapirain, B. G., Ruanova, B. F., Fernandez, Y. G., Cabrera, A., Anton-Ladislao, A., Aguirre-Larracoechea, U., & Garcıa-Monco, J. C. (2016). Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients. Journal of Headache and Pain, 17(1), 1-12. https://doi.org/10.1186/S10194-016-0593-1
dc.identifier.doi10.1186/S10194-016-0593-1
dc.identifier.eissn1129-2377
dc.identifier.issn1129-2369
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5203
dc.language.isoeng
dc.publisherSpringer-Verlag Italia s.r.l.
dc.rights© 2016 Gomez-Beldarrain et al.
dc.subject.otherChronic migraine
dc.subject.otherCingulate gyri
dc.subject.otherCognitive reserve
dc.subject.otherFractional anisotropy
dc.subject.otherInsula
dc.subject.otherMigraine
dc.subject.otherUncinate fasciculus
dc.titleRight fronto-insular white matter tracts link cognitive reserve and pain in migraine patientsen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage12
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleJournal of Headache and Pain
oaire.citation.volume17
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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