Characterization of the 1H-MRS metabolite spectra in transgender men with gender dysphoria and cisgender people

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dc.contributor.authorCollet, Sarah
dc.contributor.authorBhaduri, Sourav
dc.contributor.authorKiyar, Meltem
dc.contributor.authorT’Sjoen, Guy
dc.contributor.authorMueller, Sven C.
dc.contributor.authorGuillamon, Antonio
dc.date.accessioned2025-09-30T10:37:42Z
dc.date.available2025-09-30T10:37:42Z
dc.date.issued2021-06-14
dc.date.updated2025-09-30T10:37:42Z
dc.description.abstractMuch research has been conducted on sexual differences of the human brain to determine whether and to what extent a brain gender exists. Consequently, a variety of studies using different neuroimaging techniques attempted to identify the existence of a brain phenotype in people with gender dysphoria (GD). However, to date, brain sexual differences at the metabolite level using magnetic resonance spectroscopy (1H-MRS) have not been explored in transgender people. In this study, 28 cisgender men (CM) and 34 cisgender women (CW) and 29 transgender men with GD (TMGD) underwent1H-MRS at 3 Tesla MRI to characterize common brain metabolites. Specifically, levels of N–acetyl aspartate (NAA), choline (Cho), creatine (Cr), glutamate and glutamine (Glx), and myo-inositol + glycine (mI + Gly) were assessed in two brain regions, the amygdala-anterior hippocampus and the lateral parietal cortex. The results indicated a sex-assigned at birth pattern for Cho/Cr in the amygdala of TMGD. In the parietal cortex, a sex-assigned at birth and an intermediate pattern were found. Though assessed post-hoc, exploration of the age of onset of GD in TMGD demonstrated within-group differences in absolute NAA and relative Cho/Cr levels, suggestive for a possible developmental trend. While brain metabolite levels in TMGD resembled those of CW, some interesting findings, such as modulation of metabolite concentrations by age of onset of GD, warrant future inquiry.en
dc.description.sponsorshipThis collaboration was supported by Antonio Guillamon from UNED, Madrid, Spain grant number PGC2018-094919-B-C1 FROM Ministerio de Ciencia e Innovación, Spanish Government as well as a BOF interdisciplinary grant, grant number IOP003-18, to SCM and GT.en
dc.identifier.citationCollet, S., Bhaduri, S., Kiyar, M., T’sjoen, G., Mueller, S., & Guillamon, A. (2021). Characterization of the 1H-MRS metabolite spectra in transgender men with gender dysphoria and cisgender people. Journal of Clinical Medicine, 10(12). https://doi.org/10.3390/JCM10122623
dc.identifier.doi10.3390/JCM10122623
dc.identifier.eissn2077-0383
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3786
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2021 by the author
dc.subject.otherTransgender men
dc.subject.otherNeuroimaging
dc.subject.otherMagnetic resonance spectroscopy
dc.subject.otherSex differences
dc.subject.otherCreatine
dc.subject.otherMyo-inositol
dc.subject.otherN-acetyl-aspartate
dc.titleCharacterization of the 1H-MRS metabolite spectra in transgender men with gender dysphoria and cisgender peopleen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue12
oaire.citation.titleJournal of Clinical Medicine
oaire.citation.volume10
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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