Analyzing structural and functional brain changes related to an integrative cognitive remediation program for schizophrenia: a randomized controlled trial

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dc.contributor.authorSampedro, Agurne
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorSánchez Gómez, Pedro Manuel
dc.contributor.authorGómez Gastiasoro, Ainara
dc.contributor.authorIriarte Yoller, Nagore
dc.contributor.authorPavón, Cristóbal
dc.contributor.authorTous Espelosín, Mikel
dc.contributor.authorOjeda del Pozo, Natalia
dc.date.accessioned2025-06-04T13:52:43Z
dc.date.available2025-06-04T13:52:43Z
dc.date.issued2023-05
dc.date.updated2025-06-04T13:52:42Z
dc.description.abstractCognitive remediation has been shown to improve cognition in schizophrenia, but little is known about the specific functional and structural brain changes related to the implementation of an integrative cognitive remediation program. This study analyzed the functional and structural brain changes identified after implementing an integrative cognitive remediation program, REHACOP, in schizophrenia. The program combined cognitive remediation, social cognitive training, and functional and social skills training. The sample included 59 patients that were assigned to either the REHACOP group or an active control group for 20 weeks. In addition to a clinical and neuropsychological assessment, T1-weighted, diffusion-weighted and functional magnetic resonance images were acquired during a resting-state and during a memory paradigm, both at baseline and follow-up. Voxel-based morphometry, tract-based spatial statistics, resting-state functional connectivity, and brain activation analyses during the memory paradigm were performed. Brain changes were assessed with a 2 × 2 repeated-measure analysis of covariance for group x time interaction. Intragroup paired t-tests were also carried out. Repeated-measure analyses revealed improvements in cognition and functional outcome, but no significant brain changes associated with the integrative cognitive remediation program. Intragroup analyses showed greater gray matter volume and cortical thickness in right temporal regions at post-treatment in the REHACOP group. The absence of significant brain-level results associated with cognitive remediation may be partly due to the small sample size, which limited the statistical power of the study. Therefore, further research is needed to clarify whether the temporal lobe may be a key area involved in cognitive improvements following cognitive remediation.en
dc.description.sponsorshipThis study has been supported by the Carlos III Health Institute of the Spanish Ministry of Economy and Competitiveness (PI16/01022) and the Department of Education and Science of the Basque Government (Team A; IT946-16). AS was supported by a Fellowship from the Fundacion ´ Tatiana Pérez de Guzmán el Bueno. MTE was supported by a Fellowship from University of the Basque Country (UPV/EHU; PIF 19/40)en
dc.identifier.citationSampedro, A., Ibarretxe-Bilbao, N., Peña, J., Cabrera-Zubizarreta, A., Sánchez, P., Gómez-Gastiasoro, A., Iriarte-Yoller, N., Pavón, C., Tous-Espelosin, M., & Ojeda, N. (2023). Analyzing structural and functional brain changes related to an integrative cognitive remediation program for schizophrenia: a randomized controlled trial. Schizophrenia Research, 255, 82-92. https://doi.org/10.1016/J.SCHRES.2023.03.021
dc.identifier.doi10.1016/J.SCHRES.2023.03.021
dc.identifier.eissn1573-2509
dc.identifier.issn0920-9964
dc.identifier.urihttps://hdl.handle.net/20.500.14454/2939
dc.language.isoeng
dc.publisherElsevier B.V.
dc.rights© 2023 The Author(s)
dc.subject.otherBrain changes
dc.subject.otherCognitive remediation
dc.subject.otherGray matter
dc.subject.otherNeuroimaging
dc.subject.otherSchizophrenia
dc.titleAnalyzing structural and functional brain changes related to an integrative cognitive remediation program for schizophrenia: a randomized controlled trialen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage92
oaire.citation.startPage82
oaire.citation.titleSchizophrenia Research
oaire.citation.volume255
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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