Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents

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dc.contributor.authorMar, Javier
dc.contributor.authorLarrañaga, Igor
dc.contributor.authorIbarrondo, Oliver
dc.contributor.authorGonzález-Pinto, Ana
dc.contributor.authorLas Hayas Rodríguez, Carlota
dc.contributor.authorFullaondo, Ane
dc.contributor.authorIzco-Basurko, Irantzu
dc.contributor.authorAlonso, Jordi
dc.contributor.authorZorrilla, Iñaki
dc.contributor.authorFernández Sevillano, Jessica
dc.contributor.authorde Manuel Keenoy, Esteban
dc.date.accessioned2025-07-10T08:21:38Z
dc.date.available2025-07-10T08:21:38Z
dc.date.issued2023-03-17
dc.date.updated2025-07-10T08:21:38Z
dc.description.abstractBACKGROUND: As mental health in adulthood is related to mental status during adolescence, school-based interventions have been proposed to improve resilience. The objective of this study was to build a simulation model representing the natural history of mental disorders in childhood, adolescence and youth to estimate the cost-effectiveness of the UPRIGHT school-based intervention in promoting resilience and mental health in adolescence. METHODS: We built a discrete event simulation model fed with real-world data (cumulative incidence disaggregated into eight clusters) from the Basque Health Service database (609,381 individuals) to calculate utilities (quality-adjusted life years [QALYs]) and costs for the general population in two scenarios (base case and intervention). The model translated changes in the wellbeing of adolescents into different risks of mental illnesses for a time horizon of 30 years. RESULTS: The number of cases of anxiety was estimated to fall by 5,125 or 9,592 and those of depression by 1,269 and 2,165 if the effect of the intervention lasted 2 or 5 years respectively. From a healthcare system perspective, the intervention was cost-effective for all cases considered with incremental cost-utility ratios always lower than €10,000/QALY and dominant for some subgroups. The intervention was always dominant when including indirect and non-medical costs (societal perspective). CONCLUSIONS: Although the primary analysis of the trial did not did not detect significant differences, the UPRIGHT intervention promoting positive mental health was dominant in the economic evaluation from the societal perspective. Promoting resilience was more cost-effective in the most deprived group. Despite a lack of information about the spillover effect in some sectors, the economic evaluation framework developed principally for pharmacoeconomics can be applied to interventions to promote resilience in adolescents. As prevention of mental health disorders is even more necessary in the post-coronavirus disease-19 era, such evaluation is essential to assess whether investment in mental health promotion would be good value for money by avoiding costs for healthcare providers and other stakeholders.en
dc.description.sponsorshipThis work has been conducted within the UPRIGHT project, which is funded by the European Union’s Horizon 2020 framework programme for research and innovation under grant agreement No. 754919en
dc.identifier.citationMar, J., Larrañaga, I., Ibarrondo, O., González-Pinto, A., Hayas, C. L., Fullaondo, A., Izco-Basurko, I., Alonso, J., Zorrilla, I., Fernández-Sevillano, J., & de Manuel, E. (2023). Cost-utility analysis of the UPRIGHT intervention promoting resilience in adolescents. BMC psychiatry, 23(1), 178. https://doi.org/10.1186/S12888-023-04665-4
dc.identifier.doi10.1186/S12888-023-04665-4
dc.identifier.eissn1471-244X
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3190
dc.language.isoeng
dc.publisherNLM (Medline)
dc.rights© The Author(s) 2023
dc.subject.otherAdolescents health
dc.subject.otherHealth policy
dc.subject.otherMental disorders
dc.subject.otherMental health
dc.subject.otherPrevention
dc.subject.otherResilience
dc.subject.otherSimulation model
dc.titleCost-utility analysis of the UPRIGHT intervention promoting resilience in adolescentsen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage
oaire.citation.issue1
oaire.citation.startPage178
oaire.citation.titleBMC psychiatry
oaire.citation.volume23
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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