Immigrant IBD patients in Spain are younger, have more extraintestinal manifestations and use more biologics than native patients

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dc.contributor.authorGutiérrez Casbas, Ana
dc.contributor.authorZapater Hernández, Pedro
dc.contributor.authorRicart, Elena
dc.contributor.authorGonzález-Vivó, Maria
dc.contributor.authorGordillo Ábalos, Jordi
dc.contributor.authorOlivares, David
dc.contributor.authorVera Mendoza, María Isabel
dc.contributor.authorMañosa, Míriam
dc.contributor.authorPérez Gisbert, Javier
dc.contributor.authorAguas, Mariam
dc.contributor.authorSánchez Rodríguez, Eugenia
dc.contributor.authorBoscá Watts, Marta Maia
dc.contributor.authorLaredo, Viviana
dc.contributor.authorCamps i Aler, Blau
dc.contributor.authorMarín-Jiménez, Ignacio
dc.contributor.authorZabana, Yamile
dc.contributor.authorMartín Arranz, María Dolores
dc.contributor.authorMuñoz Perez, Roser
dc.contributor.authorNavarro, Mercè
dc.contributor.authorSierra Moros, Eva
dc.contributor.authorMadero Velázquez, Lucía
dc.contributor.authorVela González, Milagros
dc.contributor.authorPérez Calle, José Lázaro
dc.contributor.authorSainz Arnau, Empar
dc.contributor.authorCalvet Calvo, Xavier
dc.contributor.authorArias, Lara
dc.contributor.authorMorales Alvarado, Victor Jair
dc.contributor.authorBermejo San José, Fernando
dc.contributor.authorFernández-Salazar, Luis Ignacio
dc.contributor.authorVan Domselaar, Manuel
dc.contributor.authorCastro Parga, María Luisa de
dc.contributor.authorRodríguez Gutiérrez, Cristina
dc.contributor.authorMuñoz Villafranca, Carmen
dc.contributor.authorLorente Poyatos, Rufo Humberto
dc.contributor.authorRivero Tirado, Montserrat
dc.contributor.authorIglesias Flores, Eva
dc.contributor.authorHerreros Martinez, Belen
dc.contributor.authorBusquets Casals, David
dc.contributor.authorRiera Oliver, Joan
dc.contributor.authorMartínez Montiel, Pilar
dc.contributor.authorRoldon Golet, Marta
dc.contributor.authorRoncero García-Escribano, Óscar
dc.contributor.authorHinojosa del Valle, Esther
dc.contributor.authorSierra Ausín, Mónica
dc.contributor.authorBarrio Andrés, Jesús
dc.contributor.authorFrancisco García, Ruth de
dc.contributor.authorHuguet-Malavés, Jose María
dc.contributor.authorMerino Ochoa, Olga
dc.contributor.authorCarpio López, Daniel
dc.contributor.authorGinard Vicens, Daniel
dc.contributor.authorMuñoz Núñez, José Fernando
dc.contributor.authorPiqueras, Marta
dc.contributor.authorAlmela Notari, Pedro
dc.contributor.authorArgüelles Arias, Federico
dc.contributor.authorAlcaín Martínez, Guillermo
dc.contributor.authorBujanda Fernández de Piérola, Luis
dc.contributor.authorManceñido Marcos, Noemí
dc.contributor.authorLucendo Villarín, Alfredo José
dc.contributor.authorVarela Trastoy, Pilar
dc.contributor.authorRodríguez Lago, Iago
dc.contributor.authorCharola Ramos, Laura Andrea
dc.contributor.authorSempere Robles, L.
dc.contributor.authorSese Abizanda, Eva
dc.contributor.authorBarreiro de Acosta, Manuel
dc.contributor.authorDomènech, Eugeni
dc.contributor.authorFrancés Guarinos, Rubén José
dc.date.accessioned2025-05-14T09:07:28Z
dc.date.available2025-05-14T09:07:28Z
dc.date.issued2022-02-01
dc.date.updated2025-05-14T09:07:28Z
dc.description.abstractBackground: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. Methods: Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. Results: We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. Conclusions: Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europeen
dc.identifier.citationGutiérrez A, Zapater P, Ricart E, González-Vivó M, Gordillo J, Olivares D, Vera I, Mañosa M, Gisbert JP, Aguas M, Sánchez-Rodríguez E, Bosca-Watts M, Laredo V, Camps B, Marín-Jiménez I, Zabana Y, Martín-Arranz MD, Muñoz R, Navarro M, Sierra E, Madero L, Vela M, Pérez-Calle JL, Sainz E, Calvet X, Arias L, Morales V, Bermejo F, Fernández-Salazar L, Van Domselaar M, De Castro L, Rodríguez C, Muñoz-Villafranca C, Lorente R, Rivero M, Iglesias E, Herreros B, Busquets D, Riera J, Martínez-Montiel MP, Roldón M, Roncero O, Hinojosa E, Sierra M, Barrio J, De Francisco R, Huguet J, Merino O, Carpio D, Ginard D, Muñoz F, Piqueras M, Almela P, Argüelles-Arias F, Alcaín G, Bujanda L, Manceñido N, Lucendo AJ, Varela P, Rodríguez-Lago I, Ramos L, Sempere L, Sesé E, Barreiro-de Acosta M, Domènech E and Francés R (2022). Immigrant IBD patients in Spain are younger, have more extraintestinal manifestations and use more biologics than native patients. Frontiers in Medicine, 9. https://doi.org/10.3389/FMED.2022.823900
dc.identifier.doi10.3389/FMED.2022.823900
dc.identifier.eissn2296-858X
dc.identifier.urihttps://hdl.handle.net/20.500.14454/2748
dc.language.isoeng
dc.publisherFrontiers Media
dc.rights© 2022 Gutiérrez, Zapater, Ricart, González-Vivó, Gordillo, Olivares, Vera, Mañosa, Gisbert, Aguas, Sánchez-Rodríguez, Bosca-Watts, Laredo, Camps, Marín-Jiménez, Zabana, Martín-Arranz, Muñoz, Navarro, Sierra, Madero, Vela, Pérez-Calle, Sainz, Calvet, Arias, Morales, Bermejo, Fernández-Salazar, Van Domselaar, De Castro, Rodríguez, Muñoz-Villafranca, Lorente, Rivero, Iglesias, Herreros, Busquets, Riera, Martínez-Montiel, Roldón, Roncero, Hinojosa, Sierra, Barrio, De Francisco, Huguet, Merino, Carpio, Ginard, Muñoz, Piqueras, Almela, Argüelles-Arias, Alcaín, Bujanda, Manceñido, Lucendo, Varela, Rodríguez-Lago, Ramos, Sempere, Sesé, Barreiro-de Acosta, Domènech and Francés
dc.subject.otherBiologics
dc.subject.otherCrohn's disease
dc.subject.otherImmigrant
dc.subject.otherInflammatory bowel disease
dc.subject.otherPhenotype
dc.subject.otherUlcerative colitis
dc.titleImmigrant IBD patients in Spain are younger, have more extraintestinal manifestations and use more biologics than native patientsen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.titleFrontiers in Medicine
oaire.citation.volume9
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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