Comparison of ultrasound speed-of-sound of the lower extremity and lumbar muscle assessed with computed tomography for muscle loss assessment

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dc.contributor.authorRuby, Lisa
dc.contributor.authorSanabria Martín, Sergio José
dc.contributor.authorSaltybaeva, Natalia
dc.contributor.authorFrauenfelder, Thomas
dc.contributor.authorAlkadhi, Hatem
dc.contributor.authorRominger, Martha B.
dc.date.accessioned2026-03-13T11:38:16Z
dc.date.available2026-03-13T11:38:16Z
dc.date.issued2021-05-28
dc.date.updated2026-03-13T11:38:16Z
dc.description.abstractTo compare the speed of propagation of ultrasound (US) waves (SoS) of the lower leg with the clinical reference standard computed tomography (CT) at the level of lumbar vertebra 3 (L3) for muscle loss assessment. Both calf muscles of 50 patients scheduled for an abdominal CT were prospectively examined with ultrasound. A plexiglas-reflector located on the opposite side of the probe with the calf in between was used as a timing reference for SoS (m/s). CT measurements were performed at the level of L3 and included area (cm2) and attenuation (HU) of the psoas muscle, abdominal muscles, subcutaneous fat, visceral fat and abdominal area. Correlations between SoS, body mass index (BMI) and CT were determined using Pearson's correlation coefficient. Based on reported CT sarcopenia threshold values, receiver operating characteristic (ROC) analysis was performed for SoS. Inter-examiner agreement was assessed with the median difference, inter-quartile range (IQR) and intraclass correlation coefficients. SoS of the calf correlated moderately with abdominal muscle attenuation (r=0.48; P<.001), psoas muscle attenuation (r=0.40; P<.01), abdominal area (r=-0.44; P<.01) and weakly with subcutaneous fat area (r=-0.37; P<.01). BMI correlated weakly with psoas attenuation (r=-0.28; P<.05) and non-significantly with abdominal muscle attenuation. Normalization with abdominal area resulted in moderate correlations with abdominal muscle area for SoS (r=0.43; P<.01) and BMI (r=-0.46; P<.001). Based on sarcopenia threshold values for skeletal muscle attenuation (SMRA), area under curve (AUC) for SoS was 0.724. Median difference between both examiners was-3.4 m/s with IQR=15.1 m/s and intraclass correlation coefficient=0.794. SoS measurements of the calf are moderately accurate based on CT sarcopenia threshold values, thus showing potential for muscle loss quantification.en
dc.description.sponsorshipThis project has been generously supported by a donation from Dr. Hans-Peter Wild to the USZ Foundation. Sergio J. Sanabria was additionally funded by the Gottfried und Julia Bangerter-Rhyner-Foundation (grant number 0141/2019)en
dc.identifier.citationRuby, L., Sanabria, S. J., Saltybaeva, N., Frauenfelder, T., Alkadhi, H., & Rominger, M. B. (2021). Comparison of ultrasound speed-of-sound of the lower extremity and lumbar muscle assessed with computed tomography for muscle loss assessment. Medicine (United States), 100(21). https://doi.org/10.1097/MD.0000000000025947
dc.identifier.doi10.1097/MD.0000000000025947
dc.identifier.eissn1536-5964
dc.identifier.issn0025-7974
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5439
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.subject.otherAdipose tissue
dc.subject.otherSkeletal muscle
dc.subject.otherTomography
dc.subject.otherUltrasonography
dc.subject.otherX-ray computed tomography
dc.titleComparison of ultrasound speed-of-sound of the lower extremity and lumbar muscle assessed with computed tomography for muscle loss assessmenten
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue21
oaire.citation.titleMedicine (United States)
oaire.citation.volume100
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc/4.0/
oaire.versionVoR
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