Mechanisms of functional improvement through cognitive rehabilitation in schizophrenia

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dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorSánchez Gómez, Pedro Manuel
dc.contributor.authorUriarte, José Juan
dc.contributor.authorElizagarate Zabala, Edorta
dc.contributor.authorMolina Gutiérrez, Miguel Ángel
dc.contributor.authorOjeda del Pozo, Natalia
dc.date.accessioned2026-02-23T13:23:44Z
dc.date.available2026-02-23T13:23:44Z
dc.date.issued2018-03-04
dc.date.updated2026-02-23T13:23:44Z
dc.description.abstractWhereas the efficacy of cognitive rehabilitation in schizophrenia is widely known, studies examining mechanisms for functional improvement are still scarce. The aim of the study was to examine the mediational mechanisms through which cognitive rehabilitation improves functioning in schizophrenia. One hundred and eleven schizophrenia patients were randomly assigned to either a 4-month cognitive rehabilitation group or an active control group. Patients underwent a neurocognitive battery (including processing speed, verbal memory, working memory and executive functioning) and social cognition assessment (emotion perception, theory of mind and social perception). Functioning was assessed by the combined use of a performance-based instrument, the UCSD Performance-based Skills Assessment (UPSA) and an observer-rated instrument, the Global Assessment of Functioning (GAF). The trial was registered in clinicaltrials.gov (NCT02796417). Multiple mediational analyses revealed that the effect of cognitive rehabilitation on functional improvement was partially mediated by changes in processing speed and verbal memory, but not by the domains of social cognition and negative symptoms. More specifically, verbal memory partially mediated the treatment's effect on performance-based functioning (UPSA), whereas processing speed acted as a partial mediator for observer-rated functioning (GAF). The effect of rehabilitation on functioning did not take place through all the domains that showed significant improvement. Verbal memory and processing speed emerged as the most crucial factors. However, these complex interactions need further research.en
dc.identifier.citationPeña, Ibarretxe-Bilbao, Sánchez, Uriarte, Elizagarate, Gutierrez, & Ojeda. (2018). Mechanisms of functional improvement through cognitive rehabilitation in schizophrenia. Journal of Psychiatric Research, 101, 21-27. https://doi.org/10.1016/J.JPSYCHIRES.2018.03.002
dc.identifier.doi10.1016/J.JPSYCHIRES.2018.03.002
dc.identifier.eissn1879-1379
dc.identifier.issn0022-3956
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5219
dc.language.isoeng
dc.publisherElsevier Ltd
dc.rights© 2018 The Authors
dc.subject.otherSchizophrenia
dc.subject.otherFunctional disability
dc.subject.otherNeurocognition
dc.subject.otherCognitive rehabilitation
dc.subject.otherREHACOP
dc.titleMechanisms of functional improvement through cognitive rehabilitation in schizophreniaen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage27
oaire.citation.startPage21
oaire.citation.titleJournal of Psychiatric Research
oaire.citation.volume101
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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