Effectiveness of cognitive rehabilitation in parkinson’s disease: a systematic review and meta-analysis

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dc.contributor.authorSanchez Luengos, Itsasne
dc.contributor.authorBalboa Bandeira, Yolanda
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2025-08-14T10:45:04Z
dc.date.available2025-08-14T10:45:04Z
dc.date.issued2021-05-18
dc.date.updated2025-08-14T10:45:04Z
dc.description.abstractCognitive deficits influence the quality of life of Parkinson’s disease (PD) patients. In order to reduce the impact of cognitive impairment in PD, cognitive rehabilitation programs have been developed. This study presents a systematic review and meta-analysis regarding the effectiveness of cognitive rehabilitation in non-demented PD patients. Twelve articles were selected according to PRISMA guidelines. The systematic review showed that attention, working memory, verbal memory, executive functions and processing speed were the most frequently improved domains. Meta-analysis results showed moderate effects on global cognitive status (g = 0.55) and working memory (g = 0.50); small significant effects on verbal memory (g = 0.41), overall cognitive functions (g = 0.39) and executive functions (g = 0.30); small non-significant effects on attention (g = 0.36), visual memory (g = 0.29), verbal fluency (g = 0.27) and processing speed (g = 0.24); and no effect on visuospatial and visuoconstructive abilities (g = 0.17). Depressive symptoms showed small effect (g = 0.24) and quality of life showed no effect (g = -0.07). A meta-regression was performed to examine moderating variables of overall cognitive function effects, although moderators did not explain the heterogeneity of the improvement after cognitive rehabilitation. The findings suggest that cognitive rehabilitation may be beneficial in improving cognition in non-demented PD patients, although further studies are needed to obtain more robust effects.en
dc.description.sponsorshipThis study was funded by the BBK foundation (P201902032-12/1284), the Department of Education of the Basque Government (IT946-16) and a Research Staff Training Programme Grant from the Basque Government (PRE_2018_1_0379).en
dc.identifier.citationSanchez-Luengos, I., Balboa-Bandeira, Y., Lucas-Jiménez, O., Ojeda, N., Peña, J., & Ibarretxe-Bilbao, N. (2021). Effectiveness of cognitive rehabilitation in parkinson’s disease: a systematic review and meta-analysis. Journal of Personalized Medicine, 11(5). https://doi.org/10.3390/JPM11050429
dc.identifier.doi10.3390/JPM11050429
dc.identifier.eissn2075-4426
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3363
dc.language.isoeng
dc.publisherMDPI AG
dc.rights© 2021 by the authors
dc.subject.otherCognition
dc.subject.otherCognitive rehabilitation
dc.subject.otherIntervention
dc.subject.otherParkinson’s disease (pd)
dc.titleEffectiveness of cognitive rehabilitation in parkinson’s disease: a systematic review and meta-analysisen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue5
oaire.citation.titleJournal of Personalized Medicine
oaire.citation.volume11
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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