Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance

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dc.contributor.authorRuiz de Lazcano Sánchez, Aitana
dc.contributor.authorPérez Núñez, Paula
dc.contributor.authorPallarès Sastre, Mercè
dc.contributor.authorGarcía Sanchoyerto, Maddalen
dc.contributor.authorGarcía Urquiza, Irune
dc.contributor.authorAmayra Caro, Imanol
dc.date.accessioned2025-12-01T15:42:38Z
dc.date.available2025-12-01T15:42:38Z
dc.date.issued2025-01-22
dc.date.updated2025-12-01T15:42:37Z
dc.description.abstractPurpose: The aim of the study is to analyze and compare the cognitive profile between 59 patients with long-COVID [LC; 30 of them with and 29 without a positive coronavirus disease 2019 (COVID-19) confirmatory test] and 31 patients with postural orthostatic tachycardia syndrome (POTS) and a matched group of 39 healthy control participants. Methods: Participants were examined on a battery of neuropsychological tests, including verbal memory, visuospatial abilities, attention, processing speed, verbal fluency, working memory, and visual memory. Anxious–depressive symptomatology was also analyzed and then controlled for possible influence on cognitive performance. Results: Patients with LC and POTS showed significantly lower performance compared with healthy peers. Differences on anxious and depressive symptoms were also found between the clinical and control groups, resulting in LC without a positive confirmatory test group exhibiting the highest rates of anxious symptoms. After controlling the effects of anxious–depressive symptomatology, the differences were eliminated for some of the cognitive variables, but additional differences were found between patients with LC and POTS after post hoc analysis. Conclusions: Findings from the present study contribute toward the reinforcement of the evidence on cognitive alterations associated with LC and POTS. Anxious–depressive symptomatology has to be considered in both clinical groups since it could be affecting cognitive performance.en
dc.identifier.citationRuiz de Lazcano, A., Pérez-Núñez, P., Pallarès-Sastre, M., García-Sanchoyerto, M., García, I., & Amayra, I. (2025). Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance. Clinical Autonomic Research, 35(2), 285-299. https://doi.org/10.1007/S10286-025-01106-Y
dc.identifier.doi10.1007/S10286-025-01106-Y
dc.identifier.eissn1619-1560
dc.identifier.issn0959-9851
dc.identifier.urihttps://hdl.handle.net/20.500.14454/4511
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.rights© The Author(s) 2025
dc.subject.otherCognitive assessment
dc.subject.otherDysautonomia
dc.subject.otherPOTS
dc.subject.otherPsychological symptoms
dc.subject.otherSARS-CoV-2
dc.titleLong-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performanceen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage299
oaire.citation.issue2
oaire.citation.startPage285
oaire.citation.titleClinical Autonomic Research
oaire.citation.volume35
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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