Brain degeneration in synucleinopathies based on analysis of cognition and other nonmotor features: a multimodal imaging study

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dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorDiez, Ibai
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorTijero Merino, Beatriz
dc.contributor.authorGaldos Iztueta, Marta
dc.contributor.authorMurueta-Goyena Larrañaga, Ane
dc.contributor.authorPino, Rocío del
dc.contributor.authorAcera Gil, María Ángeles
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGabilondo Cuellar, Iñigo
dc.contributor.authorOjeda del Pozo, Natalia
dc.date.accessioned2025-07-08T10:41:36Z
dc.date.available2025-07-08T10:41:36Z
dc.date.issued2023-02-15
dc.date.updated2025-07-08T10:41:36Z
dc.description.abstractBackground: We aimed to characterize subtypes of synucleinopathies using a clustering approach based on cognitive and other nonmotor data and to explore structural and functional magnetic resonance imaging (MRI) brain differences between identified clusters. Methods: Sixty-two patients (n = 6 E46K-SNCA, n = 8 dementia with Lewy bodies (DLB) and n = 48 idiopathic Parkinson’s disease (PD)) and 37 normal controls underwent nonmotor evaluation with extensive cognitive assessment. Hierarchical cluster analysis (HCA) was performed on patients’ samples based on nonmotor variables. T1, diffusion-weighted, and resting-state functional MRI data were acquired. Whole-brain comparisons were performed. Results: HCA revealed two subtypes, the mild subtype (n = 29) and the severe subtype (n = 33). The mild subtype patients were slightly impaired in some nonmotor domains (fatigue, depression, olfaction, and orthostatic hypotension) with no detectable cognitive impairment; the severe subtype patients (PD patients, all DLB, and the symptomatic E46K-SNCA carriers) were severely impaired in motor and nonmotor domains with marked cognitive, visual and bradykinesia alterations. Multimodal MRI analyses suggested that the severe subtype exhibits widespread brain alterations in both structure and function, whereas the mild subtype shows relatively mild disruptions in occipital brain structure and function. Conclusions: These findings support the potential value of incorporating an extensive nonmotor evaluation to characterize specific clinical patterns and brain degeneration patterns of synucleinopathies.en
dc.description.sponsorshipThis study was co-funded by the Michael J. Fox Foundation [RRIA 2014 Rapid Response Innovation Awards) Program (Grant ID: 10189)] and Instituto de Salud Carlos III through the project “PI14/00679” and Juan Rodes grant "JR15/00008” (IG) (Co-funded by European Regional Development Fund/European Social Fund-“Investing in your future”)en
dc.identifier.citationLucas-Jiménez, O., Ibarretxe-Bilbao, N., Diez, I., Peña, J., Tijero, B., Galdós, M., Murueta-Goyena, A., Del Pino, R., Acera, M., Gómez-Esteban, J. C., Gabilondo, I., & Ojeda, N. (2023). Brain degeneration in synucleinopathies based on analysis of cognition and other nonmotor features: a multimodal imaging study. Biomedicines, 11(2). https://doi.org/10.3390/BIOMEDICINES11020573
dc.identifier.doi10.3390/BIOMEDICINES11020573
dc.identifier.eissn2227-9059
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3169
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2023 by the authors
dc.subject.otherClustering analysis
dc.subject.otherCognition
dc.subject.otherE46K-SNCA
dc.subject.otherLewy bodies diseases
dc.subject.otherMultimodal MRI
dc.subject.otherNonmotor
dc.subject.otherParkinson’s disease
dc.subject.otherSynucleinopathies
dc.titleBrain degeneration in synucleinopathies based on analysis of cognition and other nonmotor features: a multimodal imaging studyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue2
oaire.citation.titleBiomedicines
oaire.citation.volume11
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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