Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: a tractography study

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dc.contributor.authorGómez Gastiasoro, Ainara
dc.contributor.authorZubiaurre Elorza, Leire
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorRilo Cano, Oiane
dc.contributor.authorSchretlen, David J.
dc.contributor.authorOjeda del Pozo, Natalia
dc.date.accessioned2025-10-13T14:44:51Z
dc.date.available2025-10-13T14:44:51Z
dc.date.issued2019-01-01
dc.date.updated2025-10-13T14:44:51Z
dc.description.abstractBackground: White matter (WM) alterations are well documented in schizophrenia. Abnormalities in interhemispheric fibers appear to account for altered WM asymmetry in the illness. However, the regional specificity (e.g., frontal versus occipital) of these alterations and their potential contribution to cognitive dysfunction in schizophrenia remain unknown. Methods: Forty one patients with schizophrenia and 21 healthy controls (HC) underwent diffusion-weighted imaging on a 3 Tesla MRI machine. Tract-based spatial statistic (FSL) was used to assess whole brain differences in WM. Probabilistic tractography was performed in order to separately measure frontal and occipital WM tracts. Participants also completed tests of verbal memory and processing speed. Repeated measures analyses of covariance and Pearson correlation analyses were performed. Results: A significant group x cerebral hemisphere interaction was found for fractional anisotropy (FA) (F (1,17) = 7.03; p =.017; η p 2 = 0.29) and radial diffusivity (RD) (F (1,17) = 4.84; p =.042; η p 2 = 0.22) in the frontal tract of patients versus HC. Healthy controls showed higher mean FA and lower mean RD in the left frontal tract compared to patients, who showed the opposite pattern. In patients with schizophrenia, mean FA and RD in the right frontal tract correlated with verbal memory (r = −0.68, p =.046; r = 0.77, p =.015). Conclusions: Asymmetric WM alterations were found in a frontal tract of patients with schizophrenia. Higher mean FA in the right frontal tract correlated with worse verbal memory performance, suggesting a possible contribution these brain changes to cognitive impairment in schizophrenia.en
dc.description.sponsorshipThis study was funded by NIH/NIMH (National Institute of Health, USA/National Institute of Mental Health, USA) grant 5R01MH077852–02.en
dc.identifier.citationGómez-Gastiasoro, A., Zubiaurre-Elorza, L., Peña, J., Ibarretxe-Bilbao, N., Rilo, O., Schretlen, D. J., & Ojeda, N. (2019). Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: a tractography study. NeuroImage: Clinical, 22. https://doi.org/10.1016/J.NICL.2019.101781
dc.identifier.doi10.1016/J.NICL.2019.101781
dc.identifier.eissn2213-1582
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3944
dc.language.isoeng
dc.publisherElsevier Inc.
dc.rights© 2019 The Authors
dc.subject.otherAsymmetry
dc.subject.otherCognition
dc.subject.otherNeuroimaging
dc.subject.otherSchizophrenia
dc.subject.otherTractography
dc.subject.otherWhite matter
dc.subject.otherSchizophrenia
dc.subject.otherWhite matter
dc.subject.otherAsymmetry
dc.subject.otherCognition
dc.subject.otherTractography
dc.subject.otherNeuroimaging
dc.titleAltered frontal white matter asymmetry and its implications for cognition in schizophrenia: a tractography studyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.titleNeuroImage: Clinical
oaire.citation.volume22
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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