Group-level progressive alterations in brain connectivity patterns revealed by diffusion-tensor brain networks across severity stages in Alzheimer's disease

Vista sencilla de ítem
dc.contributor.authorRasero, Javier
dc.contributor.authorAlonso Montes, Carmen
dc.contributor.authorDiez, Ibai
dc.contributor.authorOlabarrieta Landa, Laiene
dc.contributor.authorRemaki, Lakhdar
dc.contributor.authorEscudero Martínez, Iñaki
dc.contributor.authorMateos Goñi, Beatriz
dc.contributor.authorBonifazi, Paolo
dc.contributor.authorFernández Martínez, Manuel
dc.contributor.authorArango Lasprilla, Juan Carlos
dc.contributor.authorStramaglia, Sebastiano
dc.contributor.authorCortes, Jesús M.
dc.date.accessioned2026-01-14T13:07:47Z
dc.date.available2026-01-14T13:07:47Z
dc.date.issued2017-07-07
dc.date.updated2026-01-14T13:07:47Z
dc.description.abstractAlzheimer's disease (AD) is a chronically progressive neurodegenerative disease highly correlated to aging. Whether AD originates by targeting a localized brain area and propagates to the rest of the brain across disease-severity progression is a question with an unknown answer. Here, we aim to provide an answer to this question at the group-level by looking at differences in diffusion-tensor brain networks. In particular, making use of data from Alzheimer's Disease Neuroimaging Initiative (ADNI), four different groups were defined (all of them matched by age, sex and education level): G1 (N1 = 36, healthy control subjects, Control), G2 (N2 = 36, early mild cognitive impairment, EMCI), G3 (N3 = 36, late mild cognitive impairment, LMCI) and G4 (N4 = 36, AD). Diffusion-tensor brain networks were compared across three disease stages: stage I (Control vs. EMCI), stage II (Control vs. LMCI) and stage III (Control vs. AD). The group comparison was performed using the multivariate distance matrix regression analysis, a technique that was born in genomics and was recently proposed to handle brain functional networks, but here applied to diffusion-tensor data. The results were threefold: First, no significant differences were found in stage I. Second, significant differences were found in stage II in the connectivity pattern of a subnetwork strongly associated to memory function (including part of the hippocampus, amygdala, entorhinal cortex, fusiform gyrus, inferior and middle temporal gyrus, parahippocampal gyrus and temporal pole). Third, a widespread disconnection across the entire AD brain was found in stage III, affecting more strongly the same memory subnetwork appearing in stage II, plus the other new subnetworks, including the default mode network, medial visual network, frontoparietal regions and striatum. Our results are consistent with a scenario where progressive alterations of connectivity arise as the disease severity increases and provide the brain areas possibly involved in such a degenerative process. Further studies applying the same strategy to longitudinal data are needed to fully confirm this scenario.en
dc.description.sponsorshipSS acknowledges financial support from Bizkaia Talent and European Commission through COFUND with the research project BRAhMS – Brain AuraMathematical Simulation– (AYD-000-285). JR acknowledges financial support from the Minister of Education, Language Policy and Culture (Basque Government) under Doctoral Research Staff Improvement Program. JC and JC-AL acknowledge financial support from Ikerbasque (The Basque Foundation for Science) and from Ministerio Economia, Industria y Competitividad (Spain) and FEDER (grant DPI2016-79874-R). PB acknowledges financial support from Ikerbasque and from the Ministerio Economia, Industria y Competitividad (Spain) and FEDER (grant SAF2015-69484-R).en
dc.identifier.citationRasero, J., Alonso-Montes, C., Diez, I., Olabarrieta-Landa, L., Remaki, L., Escudero, I., Mateos, B., Bonifazi, P., Fernandez, M., Arango-Lasprilla, Stramaglia, S., & Cortes, J. M. (2017). Group-level progressive alterations in brain connectivity patterns revealed by diffusion-tensor brain networks across severity stages in Alzheimer’s disease. Frontiers in Aging Neuroscience, 9(JUL). https://doi.org/10.3389/FNAGI.2017.00215
dc.identifier.doi10.3389/FNAGI.2017.00215
dc.identifier.eissn1663-4365
dc.identifier.urihttps://hdl.handle.net/20.500.14454/4699
dc.language.isoeng
dc.publisherFrontiers Media S.A.
dc.titleGroup-level progressive alterations in brain connectivity patterns revealed by diffusion-tensor brain networks across severity stages in Alzheimer's diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issueJUL
oaire.citation.titleFrontiers in Aging Neuroscience
oaire.citation.volume9
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
rasero_group_2017.pdf
Tamaño:
3.44 MB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos