Anatomical correlates of category-selective visual regions have distinctive signatures of connectivity in neonates

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dc.contributor.authorCabral, Laura
dc.contributor.authorZubiaurre Elorza, Leire
dc.contributor.authorWild, Conor J.
dc.contributor.authorLinke, Annika
dc.contributor.authorCusack, Rhodri
dc.date.accessioned2025-09-04T09:13:29Z
dc.date.available2025-09-04T09:13:29Z
dc.date.issued2022-11-24
dc.date.updated2025-09-04T09:13:29Z
dc.description.abstractThe ventral visual stream is shaped during development by innate proto-organization within the visual system, such as the strong input from the fovea to the fusiform face area. In adults, category-selective regions have distinct signatures of connectivity to brain regions beyond the visual system, likely reflecting cross-modal and motoric associations. We tested if this long-range connectivity is part of the innate proto-organization, or if it develops with postnatal experience, by using diffusion-weighted imaging to characterize the connectivity of anatomical correlates of category-selective regions in neonates (N = 445), 1–9 month old infants (N = 11), and adults (N = 14). Using the HCP data we identified face- and place- selective regions and a third intermediate region with a distinct profile of selectivity. Using linear classifiers, these regions were found to have distinctive connectivity at birth, to other regions in the visual system and to those outside of it. The results support an extended proto-organization that includes long-range connectivity that shapes, and is shaped by, experience-dependent development.en
dc.description.sponsorshipDeveloping Human Connectome Project (ERC Grant Agreement no. 319456); Canadian (NSERC/CIHR CHRP(201110CPG)) and European (ERC Advanced Grant ERC-2017-ADG, FOUNDCOG, 787981) funding sources; Dr. Cabral’s Postdoctoral Training (5T15 LM007059–35 Pittsburgh Biomedical Informatics Training Program; T32MH018951 Child & Adolescent Mental Health Research Pittsburgh)en
dc.identifier.citationCabral, L., Zubiaurre-Elorza, L., Wild, C. J., Linke, A., & Cusack, R. (2022). Anatomical correlates of category-selective visual regions have distinctive signatures of connectivity in neonates. Developmental Cognitive Neuroscience, 58. https://doi.org/10.1016/J.DCN.2022.101179
dc.identifier.doi10.1016/J.DCN.2022.101179
dc.identifier.eissn1878-9307
dc.identifier.issn1878-9293
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3497
dc.language.isoeng
dc.publisherElsevier Ltd
dc.rights© 2023 The Authors
dc.subject.otherClassification
dc.subject.otherDiffusion MRI
dc.subject.otherInfant
dc.subject.otherNeuroimaging
dc.subject.otherTractography
dc.subject.otherVision
dc.titleAnatomical correlates of category-selective visual regions have distinctive signatures of connectivity in neonatesen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.titleDevelopmental Cognitive Neuroscience
oaire.citation.volume58
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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