Putative role of MCT1 rs1049434 polymorphism in high-intensity endurance performance: concept and basis to understand possible individualization stimulus

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dc.contributor.authorRamírez de la Piscina, Xabier
dc.contributor.authorÁlvarez Herms, Jesús
dc.contributor.authorBonilla, Diego A.
dc.contributor.authorCastañeda Babarro, Arkaitz
dc.contributor.authorLarruskain, Jon
dc.contributor.authorDiaz Ramírez, Julen
dc.contributor.authorAhmetov, Ildus I.
dc.contributor.authorMartínez Ascensión, Alex
dc.contributor.authorKreider, Richard B.
dc.contributor.authorOdriozola Martínez, Adrián
dc.date.accessioned2025-06-06T10:57:21Z
dc.date.available2025-06-06T10:57:21Z
dc.date.issued2021-10-18
dc.date.updated2025-06-06T10:57:21Z
dc.description.abstractMonocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La-) producer and La- recipient (consumer) cells. Previous studies have suggested that the MCT1 A1470T genotype could be related to different physical performance pheno-types. This study followed the guidelines for Strengthening the Reporting of Genetic Association Studies (STREGA) and aimed to evaluate the distribution of the MCT1 polymorphism rs1049434 in endurance-trained athletes compared to the untrained population. Moreover, this study explored the potential influence of the polymorphism alleles phenotypes on high-intensity exercise performance. In a cross-sectional study fashion, a total of 85 triathletes from northern Spain were genotyped for MCT1 rs1049434 and compared to a control group of 107 healthy male participants (1000 Genomes Research Study for Iberian Populations in Spain). All athletes performed a 30 s Wingate all-out test (WAnT) on a cycle ergometer. Peak and mean power (absolute and relative) were measured. After verification of the Hardy–Weinberg equilibrium, the findings indicated that the MCT1 TT genotype was overrepresented in triathletes in comparison to the genotypic frequency of the general Spanish population. No significant associations were found between any MCT1 genotype and peak or mean power performance in the WAnT. Further studies are required to understand the relationship among MCT1 A1470T polymorphism, endurance-trained athletes, and high-intensity performance.en
dc.description.sponsorshipThe study was supported by the School of Science and Technology at University of the Basque Country (UPV/EHU)en
dc.identifier.citationPiscina-Viúdez, X. R. d. l., Álvarez-Herms, J., Bonilla, D. A., Castañeda-Babarro, A., Larruskain, J., Díaz-Ramírez, J., Ahmetov, I. I., Martínez-Ascensión, A., Kreider, R. B., & Odriozola-Martínez, A. (2021). Putative role of MCT1 rs1049434 polymorphism in high-intensity endurance performance: concept and basis to understand possible individualization stimulus. Sports, 9(10). https://doi.org/10.3390/SPORTS9100143
dc.identifier.doi10.3390/SPORTS9100143
dc.identifier.eissn2075-4663
dc.identifier.urihttps://hdl.handle.net/20.500.14454/2961
dc.language.isoeng
dc.publisherMDPI
dc.rights© 2021 by the authors
dc.subject.otherLactate
dc.subject.otherGenetics
dc.subject.otherEndurance
dc.subject.otherMetabolism
dc.subject.otherMusculoskeletal
dc.subject.otherPerformance
dc.titlePutative role of MCT1 rs1049434 polymorphism in high-intensity endurance performance: concept and basis to understand possible individualization stimulusen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue10
oaire.citation.titleSports
oaire.citation.volume9
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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