Understanding endothelial dysfunction and its role in ischemic stroke after the outbreak of recanalization therapies

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dc.contributor.authorRiva Juez, Patricia de la
dc.contributor.authorMarta Enguita, Juan
dc.contributor.authorRodríguez-Antigüedad Muñoz, Jon
dc.contributor.authorBergareche, Alberto
dc.contributor.authorLópez de Munain Arregui, Adolfo
dc.date.accessioned2025-06-06T10:32:54Z
dc.date.available2025-06-06T10:32:54Z
dc.date.issued2024-10-29
dc.date.updated2025-06-06T10:32:54Z
dc.description.abstractDespite recent advances in treatment options, stroke remains a highly prevalent and devastating condition with significant socioeconomic impact. Recanalization therapies, including intravenous thrombolysis and endovascular treatments, have revolutionized stroke management and prognosis, providing a promising framework for exploring new therapeutic strategies. Endothelial dysfunction plays a critical role in the pathophysiology, progression, and prognosis of stroke. This review aims to synthesize the current evidence regarding the involvement of the nitric oxide (NO)/endothelium pathway in ischemic stroke, with a particular focus on aging, response to recanalization therapies, and therapeutic approaches. While significant progress has been made in recent years in understanding the relationship between endothelial dysfunction and stroke, many uncertainties persist, and although treatments targeting this pathway are promising, they have yet to demonstrate clear clinical benefits.en
dc.description.sponsorshipThis research and APC of this manuscript were funded by a grant provided to the corresponding author as a principal investigator by the Health Department of the Basque Government in Spain in 2017 (number: 2017111003)en
dc.identifier.citationde la Riva, P., Marta-Enguita, J., Rodríguez-Antigüedad, J., Bergareche, A., & de Munain, A. L. (2024). Understanding endothelial dysfunction and its role in ischemic stroke after the outbreak of recanalization therapies [Review of Understanding endothelial dysfunction and its role in ischemic stroke after the outbreak of recanalization therapies]. International Journal of Molecular Sciences, 25(21). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/IJMS252111631
dc.identifier.doi10.3390/IJMS252111631
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://hdl.handle.net/20.500.14454/2959
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights© 2024 by the authors
dc.subject.otherEndothelium
dc.subject.otherNitrous oxide
dc.subject.otherRecanalization
dc.subject.otherStroke
dc.titleUnderstanding endothelial dysfunction and its role in ischemic stroke after the outbreak of recanalization therapiesen
dc.typereview article
dcterms.accessRightsopen access
oaire.citation.issue21
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.citation.volume25
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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