Long-term effects of cognitive rehabilitation on brain, functional outcome and cognition in Parkinson's disease

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dc.contributor.authorDíez Cirarda, María
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGómez Beldarrain, María Ángeles
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2026-03-04T10:23:45Z
dc.date.available2026-03-04T10:23:45Z
dc.date.issued2018-01
dc.date.updated2026-03-04T10:23:45Z
dc.description.abstractCognitive rehabilitation has demonstrated efficacy inproducing short-term cognitive and brain changes in patients with Parkinson’sdisease (PD). To date, no study has assessed the long-term effects of cognitiverehabilitation using neuroimaging techniques in PD. The aim was to assess thelongitudinal effects of a 3-month cognitive rehabilitation programme evaluatingthe cognitive, behavioural and neuroimaging changes after 18 months. Fifteen patients with PD underwent a cognitive, behavioural andneuroimaging assessment at pre-treatment (T 0), post-treatment (T 1 ) and after18 months (T 2 ). This study examined the long-term effects (from T 0 to T2)and the maintenance of the changes (from T1 to T2 ). T1-weighted, diffusion-weighted, functional magnetic resonance imaging during both a resting-stateand a memory paradigm were acquired. Voxel-based morphometry and tract-based spatial statistics were used for grey and white matter analyses. A region-of-interest-to-region-of-interest approach was used for resting-state functionalconnectivity (FC) and a model-based approach was used for brain activationduring the memory paradigm. Patients with PD showed increased cognitive performance, decreasedfunctional disability, increased brain FC and activation at T2 compared with T0(P < 0.05, FDR). Moreover, patients showed maintenance of the improvementsin cognition and functionality, and maintenance of the increased brain FC andactivation at T2 compared with T1. However, significant grey matter reductionand alterations of white matter integrity were found at T2 (P < 0.05, FWE). Findings suggest that the improved cognitive performance andincreased brain FC and activation after cognitive rehabilitation were signifi-cantly maintained after 18 months in patients with PD, despite the structuralbrain changes, consistent with a progression of neurodegenerative processes.en
dc.description.sponsorshipSupported by Department of Health of the Basque Government (2011111117), Spanish Ministry of Economy and Competitiveness (PSI2012-32441) and Department of Education and Science of the Basque Government (Equipo A) (IT946-16)en
dc.identifier.citationDíez-Cirarda, Ojeda, Peña, Cabrera-Zubizarreta, Lucas-Jiménez, Gómez-Esteban, Gómez-Beldarrain, & Ibarretxe-Bilbao. (2018). Long-term effects of cognitive rehabilitation on brain, functional outcome and cognition in Parkinson’s disease. European Journal of Neurology, 25(1), 5-12. https://doi.org/10.1111/ENE.13472
dc.identifier.doi10.1111/ENE.13472
dc.identifier.eissn1468-1331
dc.identifier.issn1351-5101
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5327
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd.
dc.rights© 2017 The Authors
dc.subject.otherBrain changes
dc.subject.otherBrain plasticity
dc.subject.otherCognitive rehabilitation
dc.subject.otherFunctional disability
dc.subject.otherLongitudinal
dc.subject.otherParkinson's disease
dc.titleLong-term effects of cognitive rehabilitation on brain, functional outcome and cognition in Parkinson's diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage12
oaire.citation.issue1
oaire.citation.startPage5
oaire.citation.titleEuropean Journal of Neurology
oaire.citation.volume25
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc/4.0/
oaire.versionVoR
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