Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease

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dc.contributor.authorKioroglou, Dimitrios
dc.contributor.authorEgia Mendikute, Leire
dc.contributor.authorPalazón García, Francisco de Asís
dc.contributor.authorBarreiro de Acosta, Manuel
dc.contributor.authorRodríguez Lago, Iago
dc.contributor.author Martínez Marigorta, Urko
dc.date.accessioned2025-07-04T09:59:00Z
dc.date.available2025-07-04T09:59:00Z
dc.date.issued2025-05-22
dc.date.updated2025-07-04T09:59:00Z
dc.description.abstractDespite the increasing incidence of Crohn’s disease (CD), its early immune disturbances have not all been described yet. We analysed single-cell RNASeq data from peripheral blood mononuclear cells of patients with incidentally-diagnosed CD, and compared their gene expression profile to healthy individuals. The main aim of our study was to perform an exploratory analysis of how the subclinical inflammatory process is modifying the individual’s immunologic environment while the patient is still in the preclinical period.en
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministry of Science MCIN/AEI/10.13039/501100011033 and by ERDF/EU (PID2019-108244RA-I00 and PID2023-151379OB-I00 to U.M.M, PID2019-107956RA-I00 to A.P., RYC2020-030632-I to U.M.M, RYC2018-024183-I to A.P., CEX2021-001136-S to U.M.M and D.K), ”la Caixa” Foundation (ID 100010434, fellowship code LCF/BQ/LI18/11630001 to U.M.M and LCF/PR/HR21/52410009 to A.P., and the European Research Council (ERC) (grant number: ERC-2018-StG 804236-NEXTGEN-IO to A.P. IR-L is funded by a research grant from Gobierno Vasco – Eusko Jaurlaritza (grant number: 2020111061 and 2023222006). The EARLY study is funded by an IIS Grant from AbbVie, Programa Estatal de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del sistema de I+D+i (PID2019-108244RA-I00), GETECCU-Pfizer grant, Ayudas a Proyectos de Investigación y Desarrollo en Salud del Departamento de Salud del Gobierno Vasco (2020111061), and the 10x Genomics Core Lab Grant Programen
dc.identifier.citationKioroglou, D., Egia-Mendikute, L., Palazon, A., Barreiro-de Acosta, M., Rodríguez-Lago, I., & Marigorta, U. M. (2025). Single-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s disease. Frontiers in Immunology, 16. https://doi.org/10.3389/FIMMU.2025.1539830
dc.identifier.doi10.3389/FIMMU.2025.1539830
dc.identifier.eissn1664-3224
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3145
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.rights© 2025 Kioroglou, Egia-Mendikute, Palazon, Barreiro-de Acosta, Rodríguez-Lago and Marigorta
dc.subject.otherCrohn’s disease
dc.subject.otherIBD
dc.subject.otherPBMC
dc.subject.otherPreclinical
dc.subject.otherScRNAseq
dc.titleSingle-cell analysis reveals significant transcriptomic alterations in preclinical Crohn’s diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.titleFrontiers in Immunology
oaire.citation.volume16
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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