An update of clinical, epidemiological, and psychosocial features in Gamma-Sarcoglycanopathy
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2023-04-03
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Multidisciplinary Digital Publishing Institute (MDPI)
Resumen
Limb-girdle muscular dystrophies (LGMDs) represent a group of muscle diseases due to monogenic mutations encoding muscle proteins that are defective for heterozygous and homozygous mutations prevalent in certain regions. Advances in knowledge of their pathophysiology have shed light on these rare diseases, which were, until recently, difficult to diagnose. This paper has described the process of diagnosis in autosomal recessive limb-girdle dystrophy that in Tunisia are due to the c.521del mutation in gamma-sarcoglycanopathy and to ethnically specific mutations in other countries such as Italy. The epidemiology, pathophysiology clinical features, and the main socioeconomic needs as well as research progress are discussed. We discuss an Italian case for its psychosocial impact and socioeconomic consideration and compare this case with Tunisian patients.
Palabras clave
Gamma-sarcoglycanopathy
Limb-girdle muscular dystrophy
Quality of life
Socioeconomic impact
Tunisian muscular dystrophy
Limb-girdle muscular dystrophy
Quality of life
Socioeconomic impact
Tunisian muscular dystrophy
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Chabbi, N., Angelini, C., & Rodriguez, A. A. (2023). An update of clinical, epidemiological, and psychosocial features in Gamma-Sarcoglycanopathy [Review of An Update of Clinical, Epidemiological, and Psychosocial Features in Gamma-Sarcoglycanopathy]. Muscles, 2(2), 164-176. Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/MUSCLES2020012