Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review

Vista sencilla de ítem
dc.contributor.authorMurillo García, Nancy
dc.contributor.authorBarrio Martínez, Sara
dc.contributor.authorSetién Suero, Esther
dc.contributor.authorSoler García, Jordi
dc.contributor.authorPapiol Miró, Sergi
dc.contributor.authorFatjó-Vilas, Mar
dc.contributor.authorAyesa Arriola, Rosa
dc.date.accessioned2025-09-04T08:27:50Z
dc.date.available2025-09-04T08:27:50Z
dc.date.issued2022-09-06
dc.date.updated2025-09-04T08:27:50Z
dc.description.abstractTo study whether there is genetic overlap underlying the risk for schizophrenia spectrum disorders (SSDs) and low intelligence quotient (IQ), we reviewed and summarized the evidence on genetic variants associated with both traits. We performed this review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and preregistered it in PROSPERO. We searched the Medline databases via PubMed, PsycInfo, Web of Science and Scopus. We included studies in adults with a diagnosis of SSD that explored genetic variants (single nucleotide polymorphisms [SNPs], copy number variants [CNVs], genomic insertions or genomic deletions), estimated IQ and studied the relationship between genetic variability and both traits (SSD and IQ). We synthesized the results and assessed risk of bias using the Quality of Genetic Association Studies (Q-Genie) tool. Fifty-five studies met the inclusion criteria (45 case–control, 9 cross-sectional, 1 cohort), of which 55% reported significant associations for genetic variants involved in IQ and SSD. The SNPs more frequently explored through candidate gene studies were in COMT, DTNBP1, BDNF and TCF4. Through genome-wide association studies, 2 SNPs in CHD7 and GATAD2A were associated with IQ in patients with SSD. The studies on CNVs suggested significant associations between structural variants and low IQ in patients with SSD. Overall, primary studies used heterogeneous IQ measurement tools and had small samples. Grey literature was not screened. Genetic overlap between SSD and IQ supports the neurodevelopmental hypothesis of schizophrenia. Most of the risk polymorphisms identified were in genes relevant to brain development, neural proliferation and differentiation, and synaptic plasticity.en
dc.description.sponsorshipSupported by a “Miguel Servet” contracts (R. Ayesa-Arriola and M. Fatjó-Vilas) from the Carlos III Health Institute (CP18/00003 and CP20/00072, respectively); a “Juan de la CiervaFormación” contract (E. Setién-Suero) from the Spanish Ministry of Science and Innovation (FJC2019-042390-/AEI/10.13039/501100011033); and a predoctoral contract (N. Murillo-García) from the Valdecilla Biomedical Research Institute and the University of Cantabria (BOC49, 19 REF. IDI-13)en
dc.identifier.citationMurillo-García, N., Barrio-Martínez, S., Setién-Suero, E., Soler, J., Papiol, S., Fatjó-Vilas, M., & Ayesa-Arriola, R. (2022). Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review. Journal of Psychiatry and Neuroscience, 47(6), E393-E408. https://doi.org/10.1503/JPN.220026
dc.identifier.doi10.1503/JPN.220026
dc.identifier.eissn1488-2434
dc.identifier.issn1180-4882
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3494
dc.language.isoeng
dc.publisherCanadian Medical Association
dc.rights© 2022 CMA Impact Inc. or its licensors
dc.titleOverlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic reviewen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPageE408
oaire.citation.issue6
oaire.citation.startPageE393
oaire.citation.titleJournal of Psychiatry and Neuroscience
oaire.citation.volume47
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
murillo_overlap_2022.pdf
Tamaño:
166.33 KB
Formato:
Adobe Portable Document Format
Descargar
Colecciones
Artículos