Low-vs high-load power training on muscle quality, functional performance, and multi-omic profiles in frail older adults: protocol for the FrailPow randomized controlled trial

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dc.contributor.authorMateos Marañón, Xabier
dc.contributor.authorMartín Lesende, Iñaki
dc.contributor.authorLarrinaga Undabarrena, Arkaitz
dc.contributor.authorSánchez Isla, José Ramón
dc.contributor.authorSantisteban Leguina, Aitor
dc.contributor.authorMuñoz Pérez, Iker
dc.contributor.authorSáez Gómez de Cadiñanos, Iker
dc.contributor.author Hernández Ortiz de Urbina, Oihana
dc.contributor.authorFernández Alonso, Amaia
dc.contributor.authorRodríguez López, Ana María
dc.contributor.authorAragón Ferrao, Celia
dc.contributor.authorGómez Soto, Irene
dc.contributor.authorRío de Frutos, Xabier
dc.date.accessioned2026-05-21T08:41:01Z
dc.date.available2026-05-21T08:41:01Z
dc.date.issued2026-03-31
dc.date.updated2026-05-21T08:41:01Z
dc.description.abstractBackground: Age-related frailty represents a growing global public health challenge, as it is associated with increased risk of falls, disability, and mortality, directly impacting functional decline and quality of life in older adults. Although resistance training is widely recommended as a therapeutic strategy, evidence on the dif-ferential effects of power training, particularly low-versus high-load modalities, compared with conventional programs remains limited. Integration of multi-omics biomarkers and advanced muscle quality assessments could enable the development of more personalized and effective exercise interventions for this population. Methods: This study will be a three-arm, multicenter, randomized controlled trial. A total of 207 older adults (≥ 70 years) meeting frailty criteria will be recruited from the Osakidetza healthcare network (Basque Country, Spain). Participants will be randomly assigned to: (1) low-load power training, (2) high-load power training, or (3) traditional resistance training. Each intervention will consist of a 12-week personalized exercise program. Assessments will be conducted at baseline, post-intervention, and at 24-and 36-weeks follow-up assessments. Measures will include muscle quality, functional performance, body composition, and multi-omics biomarkers. Results: This manuscript reports the protocol of the FrailPow randomized controlled trial; therefore, no out-come data are available at the time of submission. The study will quantify longitudinal changes across pre-defined assessment time points in muscle-related outcomes, functional performance, body composition, and multi-omics biomarkers. Conclusion: FrailPow will generate robust evidence on the efficacy and safety of power training in frail older adults, distinguishing the effects of load intensity. Additionally, the study will explore the potential of multi-omics biomarkers and advanced muscle quality metrics as tools to monitor and personalize interventions. Findings will be transferable to clinical and community settings, supporting precision exercise strategies with-in the Basque public health system to promote healthy aging. Trial registration: Registered on the Open Science Framework platform: https://osf.io/yrz4h/over-view?view_only=802a2e066c1a4c85bc43d0d4ceb3b494.en
dc.description.sponsorshipThis study is supported by the Department of Health of the Basque Government (project No. 2025333038)en
dc.identifier.citationMateos-Marañón, X., Martín-Lesende, I., Larrinaga-Undabarrena, A., Sánchez-Isla, J. R., Santisteban-Leguina, A., Muñoz-Pérez, I., Sáez, I., Ortiz de Urbina, O. H., Alonso, A. F., Rodríguez, A. M. L., Ferrao, C. A., Soto, I. G., & Río, X. (2026). Low-vs high-load power training on muscle quality, functional performance, and multi-omic profiles in frail older adults: protocol for the FrailPow randomized controlled trial. Aging Pathobiology and Therapeutics, 8(1), 60-69. https://doi.org/10.31491/APT.2026.03.206
dc.identifier.doi10.31491/APT.2026.03.206
dc.identifier.eissn2690-1803
dc.identifier.urihttps://hdl.handle.net/20.500.14454/6034
dc.language.isoeng
dc.publisherAnt Publishing Corporation
dc.subject.otherFrailty
dc.subject.otherFunctional performance
dc.subject.otherGut microbiota
dc.subject.otherMulti-omics
dc.subject.otherMuscle quality
dc.subject.otherPower training
dc.titleLow-vs high-load power training on muscle quality, functional performance, and multi-omic profiles in frail older adults: protocol for the FrailPow randomized controlled trialen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage69
oaire.citation.issue1
oaire.citation.startPage60
oaire.citation.titleAging Pathobiology and Therapeutics
oaire.citation.volume8
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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