Verbal memory in Parkinson's disease: a combined DTI and fMRI study

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dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorDíez Cirarda, María
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorCabrera Zubizarreta, Alberto
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.date.accessioned2026-02-25T13:19:58Z
dc.date.available2026-02-25T13:19:58Z
dc.date.issued2015-11-21
dc.date.updated2026-02-25T13:19:58Z
dc.description.abstractBackground: While significant progress has been made to determine the functional role of specific gray matter areas underlying verbal memory in Parkinsons disease (PD), very little is known about the relationship between these regions and their underlying white matter structures. Objective: The objectives of this study were (1) to investigate verbal memory, fractional anisotropy and brain activation differences between PD patients and healthy controls (HC), (2) to explore the neuroanatomical and neurofunctional correlates of verbal memory in PD, and (3) to investigate the relationship between these neuroanatomical and neurofunctional verbal memory correlates in PD. Methods: Functional magnetic resonance imaging (fMRI) while performing a verbal memory paradigm and diffusion tensor imaging data (DTI), were acquired in 37 PD patients and 15 age-, sex-, and education-matched HC. Results: PD patients showed verbal recognition memory impairment, lower fractional anisotropy in the anterior cingulate tract, and lower brain activation in the inferior orbitofrontal cortex compared to HC. Brain activation in the inferior orbitofrontal cortex correlated significantly with verbal recognition memory impairment in PD patients. In addition, a relationship between brain activation in the inferior orbitofrontal cortex and fractional anisotropy of the uncinate fasciculus was found in PD. Conclusions: These results reveal that deficits in verbal memory in PD are accompanied by functional brain activation changes, but also have specific structural correlates related to white matter microstructural integrity.en
dc.description.sponsorshipThis study was supported by the Health Department of the Basque Government (2011111117; to Dr. Naroa Ibarretxe-Bilbao) and the Spanish Ministry of Economy and Competitiveness (PSI2012-32441; to Dr. Naroa Ibarretxe-Bilbao)en
dc.identifier.citationLucas-Jiménez, O., Díez-Cirard, M., Ojeda, N., Peña, J., Cabrera-Zubizarreta, A., & Ibarretxe-Bilbao, N. (2015). Verbal memory in Parkinson's disease: a combined DTI and fMRI study. Journal of Parkinson’s Disease, 5(4), 793-804. https://doi.org/10.3233/JPD-150623
dc.identifier.doi10.3233/JPD-150623
dc.identifier.eissn1877-718X
dc.identifier.issn1877-7171
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5245
dc.language.isoeng
dc.publisherIOS Press
dc.rights© 2015 – IOS Press and the authors.
dc.subject.otherDTI
dc.subject.otherFMRI
dc.subject.otherLearning
dc.subject.otherParkinsons disease
dc.subject.otherRecognition
dc.subject.otherVerbal memory
dc.titleVerbal memory in Parkinson's disease: a combined DTI and fMRI studyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage804
oaire.citation.issue4
oaire.citation.startPage793
oaire.citation.titleJournal of Parkinson's Disease
oaire.citation.volume5
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc/4.0/
oaire.versionVoR
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