The effects of testosterone on the brain of transgender men

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dc.contributor.authorZubiaurre Elorza, Leire
dc.contributor.authorCerdán, Sebastián
dc.contributor.authorUribe, Carme
dc.contributor.authorPérez-Laso, Carmen
dc.contributor.authorMarcos Bermejo, Alberto
dc.contributor.authorRodríguez del Cerro, María Cruz
dc.contributor.authorFernández García, Rosa
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorGuillamon, Antonio
dc.date.accessioned2025-08-14T10:51:25Z
dc.date.available2025-08-14T10:51:25Z
dc.date.issued2021-12-23
dc.date.updated2025-08-14T10:51:25Z
dc.description.abstractTransgender men (TM) experience an incongruence between the female sex assigned when they were born and their self-perceived male identity. Some TM seek for a gender affirming hormone treatment (GAHT) to induce a somatic transition from female to male through continuous administration of testosterone. GAHT seems to be relatively safe. However, testosterone produces structural changes in the brain as detected by quantitative magnetic resonance imaging. Mainly, it induces an increase in cortical volume and thickness and subcortical structural volume probably due to the anabolic effects. Animal models, specifically developed to test the anabolic hypothesis, suggest that testosterone and estradiol, its aromatized metabolite, participate in the control of astrocyte water trafficking, thereby controlling brain volume.en
dc.description.sponsorshipThis study was supported by the Spanish Ministry ofScience and Innovation [Grant No. PGC2018-094919-B-C21 to A.G., Grant No. PGC2018-094919-B-C22to R.F. and E.P., and Grant No. PSI2017-83657-P toL.Z.-E.] and a Grant No. ED431B 019/02 to E.P.C.U. was supported by the European Union’s Horizon2020 research and innovation program under theMarie Sklodowska-Curie fellowship [Grant Agree-ment 888692].en
dc.identifier.citationZubiaurre-Elorza, L., Cerdán, S., Uribe, C., Pérez-Laso, C., Marcos, A., Rodríguez Del Cerro, M. C., Fernandez, R., Pásaro, E., & Guillamon, A. (2021). The effects of testosterone on the brain of transgender men [Review of The effects of testosterone on the brain of transgender men]. Androgens, 2(1), 252-260. Mary Ann Liebert Inc. https://doi.org/10.1089/ANDRO.2021.0008
dc.identifier.doi10.1089/ANDRO.2021.0008
dc.identifier.eissn2689-4653
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3364
dc.language.isoeng
dc.publisherMary Ann Liebert Inc.
dc.rights© Leire Zubiaurre-Elorza et al., 2021
dc.subject.otherAndrogenic anabolic steroids
dc.subject.otherAstrocytes
dc.subject.otherGlutamine
dc.subject.otherMRI
dc.subject.otherTestosterone
dc.subject.otherTransgender men
dc.titleThe effects of testosterone on the brain of transgender menen
dc.typereview article
dcterms.accessRightsopen access
oaire.citation.endPage260
oaire.citation.issue1
oaire.citation.startPage252
oaire.citation.titleAndrogens
oaire.citation.volume2
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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