Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases

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dc.contributor.authorMurueta-Goyena Larrañaga, Ane
dc.contributor.authorPino, Rocío del
dc.contributor.authorReyero, Paula
dc.contributor.authorGaldos Iztueta, Marta
dc.contributor.authorArana, Begoña
dc.contributor.authorLucas Jiménez, Olaia
dc.contributor.authorAcera Gil, María Ángeles
dc.contributor.authorTijero Merino, Beatriz
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorCortés, Jesús
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGabilondo Cuellar, Iñigo
dc.date.accessioned2025-10-04T08:08:50Z
dc.date.available2025-10-04T08:08:50Z
dc.date.issued2019-09-01
dc.date.updated2025-10-04T08:08:50Z
dc.description.abstractBackground: Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. We investigated whether region-specific thickness analysis of retinal layers could improve the detection of macular atrophy and unravel its association with visual disability in Parkinson's disease. Methods: Patients with idiopathic Parkinson's disease (n = 63), dementia with Lewy bodies (n = 8), and E46K mutation carriers in the α-synuclein gene (E46K-SNCA) (n = 4) and 34 controls underwent Spectralis optical coherence tomography macular scans and a comprehensive battery of visual function and cognition tests. We computed mean retinal layer thicknesses of both eyes within 1-, 2-, 3-, and 6-mm diameter macular discs and in concentric parafoveal (1- to 2-mm, 2- to 3-mm, 1- to 3-mm) and perifoveal (3- to 6-mm) rings. Group differences in imaging parameters and their relationship with visual outcomes were analyzed. A multivariate logistic model was developed to predict visual impairment from optical coherence tomography measurements in Parkinson's disease, and cutoff values were determined with receiver operating characteristic analysis. Results: When compared with controls, patients with dementia with Lewy bodies had significant thinning of the ganglion cell–inner plexiform layer complex within the central 3-mm disc mainly because of differences in 1- to 3-mm parafoveal thickness. This parameter was strongly correlated in patients, but not in controls, with low contrast visual acuity and visual cognition outcomes (P <.05, False Discovery Rate), achieving 88% of accuracy in predicting visual impairment in Parkinson's disease. Conclusion: Our findings support that parafoveal thinning of ganglion cell–inner plexiform complex is a sensitive and clinically relevant imaging biomarker for Lewy body diseases, specifically for Parkinson's disease. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.en
dc.identifier.citationMurueta-Goyena, A., del Pino, R., Reyero, P., Galdós, M., Arana, B., Lucas-Jiménez, O., Acera, M., Tijero, B., Ibarretxe-Bilbao, N., Ojeda, N., Peña, J., Cortés, J., Gómez-Esteban, J. C., & Gabilondo, I. (2019). Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases. Movement Disorders, 34(9), 1315-1324. https://doi.org/10.1002/MDS.27728
dc.identifier.doi10.1002/MDS.27728
dc.identifier.eissn1531-8257
dc.identifier.issn0885-3185
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3865
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc.
dc.titleParafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseasesen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage1324
oaire.citation.issue9
oaire.citation.startPage1315
oaire.citation.titleMovement Disorders
oaire.citation.volume34
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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