The source of the memory impairment in Parkinson's disease: acquisition versus retrieval

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dc.contributor.authorChiaravalloti, Nancy
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorDeluca, John
dc.contributor.authorRusu, Olga
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorGarcía Gorostiaga, Inés
dc.contributor.authorOjeda del Pozo, Natalia
dc.date.accessioned2026-05-07T11:13:23Z
dc.date.available2026-05-07T11:13:23Z
dc.date.issued2014
dc.date.updated2026-05-07T11:13:23Z
dc.description.abstractMemory deficits are common in persons with Parkinson's disease (PD) even without the presence of a frank dementia. These memory deficits have traditionally been attributed to inability of patients to retrieve information from long-term memory, referred to as the "retrieval failure hypothesis." However, some studies additionally document problems in recognition memory, noted to be inconsistent with the retrieval failure hypothesis. Given the neuroanatomical abnormalities observed in the hippocampus of PD patients and the role of the hippocampus in learning new information, the current study was designed to specifically examine learning abilities in a nondemented PD sample through the application of a learning paradigm, the Open Trial Selective Reminding Test. We examined 27 patients with PD without dementia and 27 age-, gender-, and education-matched healthy controls (HCs) with a neuropsychological test battery designed to assess new learning and memory. Results indicated a significant difference between the groups in terms of their ability to learn a list of 10 semantically related words. However, once the groups were equated on learning abilities, no significant difference was noted between the PD and HC participants in recall or recognition of the newly learned material. The memory deficit observed in nondemented PD patients is thus largely the result of a deficit in learning new information. This finding should be used to guide treatment for memory deficits in persons with PD, and future research should seek to identify novel means of improving new learning in this population. © 2014 International Parkinson and Movement Disorder Society.en
dc.description.sponsorshipThis study was supported by the Health Departmentof Basque Government (2011111117; to N.I.B) and the Spanish Ministryof Economy and Competitiveness (PSI2012-32441; to N.I.B.)en
dc.identifier.citationChiaravalloti, N. D., Ibarretxe-Bilbao, N., Deluca, J., Rusu, O., Pena, J., García-Gorostiaga, I., & Ojeda, N. (2014). The source of the memory impairment in Parkinson’s disease: acquisition versus retrieval. Movement Disorders, 29(6), 765-771. https://doi.org/10.1002/MDS.25842
dc.identifier.doi10.1002/MDS.25842
dc.identifier.eissn1531-8257
dc.identifier.issn0885-3185
dc.identifier.urihttps://hdl.handle.net/20.500.14454/5888
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc.
dc.subject.otherCognition
dc.subject.otherLearning
dc.subject.otherMemory
dc.subject.otherOpen Trial Selective Reminding Test
dc.subject.otherParkinson's disease
dc.titleThe source of the memory impairment in Parkinson's disease: acquisition versus retrievalen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage771
oaire.citation.issue6
oaire.citation.startPage765
oaire.citation.titleMovement Disorders
oaire.citation.volume29
oaire.versionVoR
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