Protocol for a trial to assess the efficacy and applicability of isometric strength training in older adults with sarcopenia and dynapenia

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dc.contributor.authorLópez Torre, Iker
dc.contributor.authorMielgo Ayuso, Juan
dc.contributor.authorFernández-López, Juan Ramón
dc.contributor.authorAznar, José M.
dc.contributor.authorCastañeda Babarro, Arkaitz
dc.date.accessioned2026-10-30T09:26:17Z
dc.date.available2026-10-30T09:26:17Z
dc.date.issued2025-07-01
dc.date.updated2026-10-30T09:26:17Z
dc.description.abstractBackground: Sarcopenia (loss of muscle mass) and dynapenia (loss of strength) are prevalent in older adults aged 70 years and over. Both have an impact on their functional ability and quality of life, with type II muscle fibres being particularly affected. Although traditional resistance training (TRT) is effective, it presents technical difficulties and an increased risk of injury among this vulnerable population. Isometric strength training (IST) is a potentially safer, more accessible and more effective alternative. Objective: To describe the protocol of a single-arm, pre-post intervention trial designed to evaluate the efficacy and applicability of a 16-week IST programme on muscle strength, skeletal muscle mass, quality of life and applicability (safety, acceptability, perceived difficulty) in 18 older adults aged 70 years and above with a diagnosis of sarcopenia and dynapenia. The influence of genetic and environmental factors on the variability of response to IST will also be explored. Methodology: The participants, who have all been diagnosed with sarcopenia according to EWGSOP2 (European Working Group on Sarcopenia in Older People 2) criteria, will perform two IST sessions per week for 16 weeks. Each 30-min session will consist of one progressive set (total duration 45 s to 90 s) for each of the eight major muscle groups. This series will include phases at 20% and 40% of individual Maximal Voluntary Isometric Contraction (MVIC), culminating in 100% Maximal Effort (ME), using the CIEX SYSTEM machine with visual feedback. The primary outcome variables will be: change in knee extensor MVIC and change in Appendicular Skeletal Muscle Mass Index (ASMMI). Secondary variables will be measured (other components of sarcopenia, quality of life by EQ-5D-5L, use of Likert scales, posture and physiological variables), and saliva samples will be collected for exploratory genetic analyses. The main statistical analyses will be performed with t-tests for related samples or their non-parametric analogues. Discussion: This protocol details a specific IST intervention and a comprehensive evaluation plan. The results are expected to provide evidence on the feasibility and effects of IST among older adults with sarcopenia and dynapenia. Understanding individual variability in response, including genetic influence, could inform the design of more personalised and effective exercise strategies for this population in the future.en
dc.identifier.citationLópez, I., Mielgo-Ayuso, J., Fernández-López, J. R., Aznar, J. M., & Castañeda-Babarro, A. (2025). Protocol for a trial to assess the efficacy and applicability of isometric strength training in older adults with sarcopenia and dynapenia. Healthcare (Switzerland), 13(13). https://doi.org/10.3390/HEALTHCARE13131573
dc.identifier.doi10.3390/HEALTHCARE13131573
dc.identifier.eissn2227-9032
dc.identifier.urihttps://hdl.handle.net/20.500.14454/6859
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rightsCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland
dc.subject.otherDynapenia
dc.subject.otherIsometric resistance training
dc.subject.otherSarcopenia
dc.subject.otherTraditional resistance training
dc.subject.otherType II fibres
dc.titleProtocol for a trial to assess the efficacy and applicability of isometric strength training in older adults with sarcopenia and dynapeniaen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue13
oaire.citation.titleHealthcare (Switzerland)
oaire.citation.volume13
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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