Impact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary care

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dc.contributor.authorMartín Fernández, Jesús
dc.contributor.authorAlonso Safont, Tamara
dc.contributor.authorPolentinos Castro, Elena
dc.contributor.authorEsteban Vasallo, María Dolores
dc.contributor.authorAriza Cardiel, Gloria
dc.contributor.authorGonzález Anglada, María Isabel
dc.contributor.author Sánchez Perruca, Luis
dc.contributor.authorRodríguez Martínez, Gemma
dc.contributor.authorRotaeche del Campo, Rafael
dc.contributor.authorBilbao González, Amaia
dc.date.accessioned2025-07-10T08:46:36Z
dc.date.available2025-07-10T08:46:36Z
dc.date.issued2023-03-23
dc.date.updated2025-07-10T08:46:36Z
dc.description.abstractBackground: Hypertension is responsible for a huge burden of disease. The aim of this study was to evaluate the impact of newly diagnosed hypertension on the occurrence of kidney or cardiovascular events (K/CVEs) and on mortality among community dwellers. Methods: Retrospective cohort study, conducted from January, 2007, to December, 2018. All patients (age > 18) newly diagnosed with hypertension and no previous K/CVEs in 2007 and 2008, in the primary care centers of Madrid (Spain) (n = 71,770), were enrolled. The control group (n = 72,946) included patients without hypertension, matched by center, sex and age. The occurrence of kidney or CV events, including mortality from these causes and total mortality were evaluated using Cox regression and multistate models. Data were collected from three sources: personal data from administrative records, clinical data from medical records, and mortality data from regional and national databases. Results: The median follow-up was 138.61 months (IQR: 124.68–143.97 months). There were 32,896 K/CVEs (including 3,669 deaths from these causes) and 12,999 deaths from other causes. Adjusted for sex, smoking, diabetes and socioeconomic status, K/CVEs HR was 4.36 (95% CI: 3.80–5.00) for diagnoses before 45 years of age, 2.45(95% CI: 2.28- 2.63) for diagnosis between 45 to 54 years, and HR decreased to 1.86 (95% CI: 1.64–210) for diagnoses over age 85. Total mortality risk was only higher for hypertension diagnosed before 55 years of age (HR: 2.47, 95% CI: 1.90–3.19 for ages 18 to 44; and HR: 1.14, 95% CI: 1.02–1.28 for ages 45 to 54). Conclusion: The diagnosis of hypertension in the community environment, in patients without evidence of previous kidney or CV disease, is associated with a large increase in the risk of K/CVEs, but especially in individuals diagnosed before the age of 55. This diagnosis is only associated with an increase in kidney or cardiovascular mortality or overall mortality when it occurs before age 55.en
dc.description.sponsorshipThe study was funded by the Carlos III Health Institute (ISCIII, PI1800370) and co-financed by the European Unionen
dc.identifier.citationMartín-Fernández, J., Alonso-Safont, T., Polentinos-Castro, E., Esteban-Vasallo, M. D., Ariza-Cardiel, G., González-Anglada, M. I., Sánchez-Perruca, L., Rodríguez-Martínez, G., Rotaeche-del-Campo, R., & Bilbao-González, A. (2023). Impact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary care. BMC Primary Care, 24(1). https://doi.org/10.1186/S12875-023-02036-2
dc.identifier.doi10.1186/S12875-023-02036-2
dc.identifier.eissn2731-4553
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3191
dc.language.isoeng
dc.publisherBioMed Central Ltd
dc.rights© The Author(s) 2023
dc.subject.otherCardiovascular disease
dc.subject.otherHypertension
dc.subject.otherPrimary health care
dc.subject.otherSurvival
dc.titleImpact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary careen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue1
oaire.citation.titleBMC Primary Care
oaire.citation.volume24
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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