Differential responsiveness to exercise and cognitive remediation in physical health in people with schizophrenia: results from the CORTEX-SP study

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dc.contributor.authorTous Espelosín, Mikel
dc.contributor.authorIriarte Yoller, Nagore
dc.contributor.author Sampedro, Agurne
dc.contributor.authorLasa-Sagaseta, Iñaki
dc.contributor.authorPavón Navajas, Cristóbal
dc.contributor.authorOjeda del Pozo, Natalia
dc.contributor.authorSánchez Gómez, Pedro Manuel
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorMaldonado Martín, Sara
dc.date.accessioned2026-06-24T13:44:23Z
dc.date.available2026-06-24T13:44:23Z
dc.date.issued2026-06
dc.date.updated2026-06-24T13:44:23Z
dc.description.abstractNon-pharmacological interventions, such as exercise and cognitive remediation, have been widely investigated in people with schizophrenia (SZ), showing beneficial effects and supporting their role as complementary approaches to pharmacological treatment. Moving towards precision medicine, it is important to consider variability in individual responses. Thus, this study aimed to analyse the prevalence of responders regarding body composition, cardiorespiratory fitness (CRF), and sleep quality in people with SZ following exercise or cognitive remediation programmes. A total of 159 participants with SZ (41 ± 10 years) were randomly assigned to the treatment-as-usual (TAU, n = 53), exercise (EX, n = 59), or cognitive remediation programme (REHACOP, n = 47) groups. Anthropometric outcomes, CRF, and sleep efficiency were assessed pre- and post-intervention using standardised methodologies. The typical error (TE) was calculated to identify responders. The EX group showed the highest prevalence of responders in body mass index (21.2%) and fat mass percentage (20%). There were significant improvements in CRF in the EX group (Δ = 21.0%, p < 0.001), with a significantly higher prevalence of responders compared with the REHACOP and TAU groups (p < 0.001). Sleep efficiency also improved significantly in the EX group (Δ = 1.75%, p = 0.004), again with the highest prevalence of responders (27.7%) in this group. These findings suggest that exercise is a particularly effective strategy for enhancing physical health outcomes in people with SZ. However, cognitive remediation may still play a complementary role by supporting the cognitive resources required to maintain exercise engagement and healthy lifestyle changes.en
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Economy and Competitiveness, ‘Fondo de Investigación Sanitaria del Instituto de Salud Carlos III’ (PI16/01022). The University of the Basque Countrysupported MT‐E with a predoctoral grant (UPV/EHU, PIF19/40). TheCouncil of Vitoria‐Gasteiz provides the facilities of the Physical Activity and Health Research Centre for exercise interventionen
dc.identifier.citationTous-Espelosin, M., Iriarte-Yoller, N., Sampedro, A., Lasa-Sagaseta, I., Pavon, C., Ojeda, N., Sanchez, P., Peña, J., & Maldonado-Martín, S. (2026). Differential responsiveness to exercise and cognitive remediation in physical health in people with schizophrenia: results from the CORTEX-SP study. European Journal of Sport Science, 26(6). https://doi.org/10.1002/EJSC.70182
dc.identifier.doi10.1002/EJSC.70182
dc.identifier.eissn1536-7290
dc.identifier.issn1746-1391
dc.identifier.urihttps://hdl.handle.net/20.500.14454/6298
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.rights© 2026 The Author(s)
dc.subject.otherBody composition
dc.subject.otherCardiorespiratory fitness
dc.subject.otherResponder
dc.subject.otherSleep efficiency
dc.subject.otherBody composition
dc.subject.otherCardiorespiratory fitness
dc.subject.otherResponder
dc.subject.otherSleep efficiency
dc.titleDifferential responsiveness to exercise and cognitive remediation in physical health in people with schizophrenia: results from the CORTEX-SP studyen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.issue6
oaire.citation.titleEuropean Journal of Sport Science
oaire.citation.volume26
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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