Estimation of cognitive performance based on premorbid intelligence in Parkinson's disease

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dc.contributor.authorPino, Rocío del
dc.contributor.authorDíez Cirarda, María
dc.contributor.authorPeña Lasa, Javier
dc.contributor.authorIbarretxe Bilbao, Naroa
dc.contributor.authorOjeda del Pozo, Natalia
dc.date.accessioned2025-08-28T09:57:28Z
dc.date.available2025-08-28T09:57:28Z
dc.date.issued2020-08-26
dc.date.updated2025-08-28T09:57:28Z
dc.description.abstractBackground: The estimation of premorbid intelligence (PI) is needed for an accurate diagnosis. Objective: This study aimed to estimate the cognitive performance taking into account the PI in Parkinson's disease (PD) compared to healthy controls (HC); and to analyze the discrepancies between the current and the predicted cognitive performance based on the PI. Method: Semantic fluency, verbal and visual memory, and executive functions were assessed in 39 PD and 162 HC. A linear regression model was used to analyze the discrepancies between the predicted cognitive performance and the current raw scores through PI variables (Word Accentuation Test (WAT), Pseudo-Words (PW) Reading subtest from PROLEC-R, age, and years of education). ROC analyses were performed to assess their diagnostic properties. Results: Significant differences were found in the raw cognitive scores between patients and HC [semantic fluency (t=6.07; p<0.001), verbal memory (t=6.63; p<0.001), and executive functions (t=2.57; p=0.013), and in visual memory (t=1.97; p=0.055 marginally significant)]. Compared to HC, PD patients presented higher discrepancies between the predicted cognitive performance and the raw scores in semantic fluency, verbal memory, visual memory, executive functions (AUC=0.78, 0.78; 0.64, 0.61, respectively). Conclusion: The magnitude of the discrepancies scores between the current and the predicted cognitive performance based on PI indicates the presence of cognitive decline in the specific cognitive domain in PD patients. This study underlines the usefulness of premorbid measures and variables, such as WAT, PW, age, and years of education, to more accurately estimate the cognitive performance in PD.en
dc.description.sponsorshipThis study was supported by the Department of Health of the Basque Government [2011111117; 2011111102], Basic and Applied Research of the Basque Government [PI 2014 1 43], the Spanish Ministry of Economy and Competitiveness [PSI2012–32441], the Federation of Associations of Spanish Neuropsychology (FANPSE) and University of Deustoen
dc.identifier.citationDel Pino, R., DÍez-Cirarda, M., Peña, J., Ibarretxe-Bilbao, N., & Ojeda, N. (2020). Estimation of cognitive performance based on premorbid intelligence in Parkinson's disease. Journal of Parkinson’s Disease, 10(4), 1717-1725. https://doi.org/10.3233/JPD-202142
dc.identifier.doi10.3233/JPD-202142
dc.identifier.eissn1877-718X
dc.identifier.issn1877-7171
dc.identifier.urihttps://hdl.handle.net/20.500.14454/3419
dc.language.isoeng
dc.publisherIOS Press BV
dc.rights© 2020 – IOS Press and the authors
dc.subject.otherNeuropsychological assessment
dc.subject.otherParkinson's disease
dc.subject.otherPremorbid intelligence
dc.subject.otherPseudo-words
dc.subject.otherWAT
dc.titleEstimation of cognitive performance based on premorbid intelligence in Parkinson's diseaseen
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage1725
oaire.citation.issue4
oaire.citation.startPage1717
oaire.citation.titleJournal of Parkinson's Disease
oaire.citation.volume10
oaire.licenseConditionhttps://creativecommons.org/licenses/by/4.0/
oaire.versionVoR
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