Being born extremely preterm with low-grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhood

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dc.contributor.authorBroström, Lina
dc.contributor.authorFernández de Gamarra Oca, Lexuri
dc.contributor.authorKvanta, Hedvig
dc.contributor.authorÖrtqvist, Maria
dc.contributor.authorPadilla, Nelly
dc.contributor.authorÅdén, Ulrika
dc.date.accessioned2025-05-19T10:40:15Z
dc.date.available2025-05-19T10:40:15Z
dc.date.issued2025-05
dc.date.updated2025-05-19T10:40:15Z
dc.description.abstractAim: Our aim was to investigate the impact that low-grade intraventricular haemorrhage (IVH) had on neonatal morbidities, brain volumes and neurodevelopmental outcomes in children born extremely preterm (EPT) and compare them with children born EPT without low-grade IVH. Methods: This prospective cohort study was carried out in Stockholm, Sweden. It focused on 103 children born EPT from 2004 to 2007, at less than 27 weeks of gestation, without major brain injuries. The group with low-grade IVH, defined as grades I–II, were compared with children born EPT without IVH. Around half (45%) underwent MRI scans at 10 years of age and 55% had neurodevelopmental assessments at 12 years. Results: The low-grade IVH group was sicker during the neonatal period than the children born EPT without IVH. They had lower gestational ages at birth, more days on mechanical ventilation, a higher incidence of necrotising enterocolitis and were more likely to need surgical ligation of patent ductus arteriosus. However, they did not have significantly smaller brain volumes at 10 years of age or worse neurodevelopmental outcomes at 12 years of age. Conclusion: Brain volumes or neurodevelopment were not affected in children born EPT with low-grade IVH, compared to children born EPT without IVH.en
dc.description.sponsorshipRegional Agreement on Medical Training and Clinical Research, Grant/Award Number: ALF SLL 20170243; the Department of Education of the Basque Government, Grant/Award Number: PRE_2019_1_0105; Swedish Medical Research Council, Grant/Award Number: 2017-03043; Svenska Läkaresällskapet; the Swedish Brain Foundation, Grant/Award Number: FO2019-0045; the Swedish Order of Freemasons in Stockholmen
dc.identifier.citationBroström, L., de Gamarra-Oca, L. F., Kvanta, H., Örtqvist, M., Padilla, N., & Ådén, U. (2025). Being born extremely preterm with low-grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhood. Acta Paediatrica, International Journal of Paediatrics, 114(5), 972-979. https://doi.org/10.1111/APA.17517
dc.identifier.doi10.1111/APA.17517
dc.identifier.eissn1651-2227
dc.identifier.issn0803-5253
dc.identifier.urihttps://hdl.handle.net/20.500.14454/2768
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.rights© 2024 The Author(s)
dc.subject.otherExtremely preterm
dc.subject.otherLow-grade intraventricular haemorrhage
dc.subject.otherMagnetic resonance imaging
dc.subject.otherNeonatal morbidities
dc.subject.otherNeurodevelopmental outcomes
dc.titleBeing born extremely preterm with low-grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhooden
dc.typejournal article
dcterms.accessRightsopen access
oaire.citation.endPage979
oaire.citation.issue5
oaire.citation.startPage972
oaire.citation.titleActa Paediatrica, International Journal of Paediatrics
oaire.citation.volume114
oaire.licenseConditionhttps://creativecommons.org/licenses/by-nc-nd/4.0/
oaire.versionVoR
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