Examinando por Autor "Uribe, Carme"

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    Data for functional MRI connectivity in transgender people with gender incongruence and cisgender individuals
    (Elsevier Inc., 2020-05-15) Uribe, Carme; Junqué i Plaja, Carme; Gómez Gil, Esther; Abos Ortega, Alexandra; Mueller, Sven C.; Guillamon, Antonio
    We provide T2*-weighted and T1-weighted images acquired on a 3T MRI scanner obtained from 17 transwomen and 29 transmen with gender incongruence; and 22 ciswomen and 19 cismen that identified themselves to the sex assigned at birth. Data from three different techniques that describe global and regional connectivity differences within functional resting-state networks in transwomen and transmen with early-in-life onset gender incongruence are provided: (1) we obtained spatial maps from data-driven independent component analysis using the melodic tool from FSL software; (2) we provide the functional networks interactions of two functional atlases’ seeds from a seed-to-seed approach; (3) and global graph-theoretical metrics such as the smallworld organization, and the segregation and integration properties of the networks. Interpretations of the present dataset can be found in the original article, doi:10.1016/j.neuroimage.2020.116613 [1]. The original and processed nifti images are available in Mendeley datasets. In addition, correlation matrices for the seed-to-seed and graph-theory analyses as well as the graph-theoretical measures were made available in Matlab files. Finally, we present supplementary information for the original article.
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    The effects of testosterone on the brain of transgender men
    (Mary Ann Liebert Inc., 2021-12-23) Zubiaurre Elorza, Leire; Cerdán, Sebastián; Uribe, Carme; Pérez-Laso, Carmen ; Marcos Bermejo, Alberto; Rodríguez del Cerro, María Cruz; Fernández García, Rosa; Pásaro, Eduardo; Guillamon, Antonio
    Transgender men (TM) experience an incongruence between the female sex assigned when they were born and their self-perceived male identity. Some TM seek for a gender affirming hormone treatment (GAHT) to induce a somatic transition from female to male through continuous administration of testosterone. GAHT seems to be relatively safe. However, testosterone produces structural changes in the brain as detected by quantitative magnetic resonance imaging. Mainly, it induces an increase in cortical volume and thickness and subcortical structural volume probably due to the anabolic effects. Animal models, specifically developed to test the anabolic hypothesis, suggest that testosterone and estradiol, its aromatized metabolite, participate in the control of astrocyte water trafficking, thereby controlling brain volume.
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    A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease
    (Nature Research, 2024-12) Oltra, Javier; Segura, Barbara; Strafella, Antonio P.; Eimeren, Thilo van; Ibarretxe Bilbao, Naroa; Díez Cirarda, María; Eggers, Carsten; Lucas Jiménez, Olaia; Monté Rubio, Gemma Cristina; Ojeda del Pozo, Natalia; Peña Lasa, Javier; Ruppert, Marina C.; Sala Llonch, Roser; Theis, Hendrik; Uribe, Carme; Junqué i Plaja, Carme
    Clinical, cognitive, and atrophy characteristics depending on sex have been previously reported in Parkinson’s disease (PD). However, though sex differences in cortical gray matter measures in early drug naïve patients have been described, little is known about differences in cortical thickness (CTh) as the disease advances. Our multi-site sample comprised 211 non-demented PD patients (64.45% males; mean age 65.58 ± 8.44 years old; mean disease duration 6.42 ± 5.11 years) and 86 healthy controls (50% males; mean age 65.49 ± 9.33 years old) with available T1-weighted 3 T MRI data from four international research centers. Sex differences in regional mean CTh estimations were analyzed using generalized linear models. The relation of CTh in regions showing sex differences with age, disease duration, and age of onset was examined through multiple linear regression. PD males showed thinner cortex than PD females in six frontal (bilateral caudal middle frontal, bilateral superior frontal, left precentral and right pars orbitalis), three parietal (bilateral inferior parietal and left supramarginal), and one limbic region (right posterior cingulate). In PD males, lower CTh values in nine out of ten regions were associated with longer disease duration and older age, whereas in PD females, lower CTh was associated with older age but with longer disease duration only in one region. Overall, male patients show a more widespread pattern of reduced CTh compared with female patients. Disease duration seems more relevant to explain reduced CTh in male patients, suggesting worse prognostic over time. Further studies should explore sex-specific cortical atrophy trajectories using large longitudinal multi-site data
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    Parameters from site classification to harmonize MRI clinical studies: application to a multi-site Parkinson's disease dataset
    (John Wiley & Sons, Inc, 2022-03-19) Monté Rubio, Gemma Cristina; Segura, Barbara; Strafella, Antonio P.; Eimeren, Thilo van; Ibarretxe Bilbao, Naroa; Díez Cirarda, María ; Eggers, Carsten ; Lucas Jiménez, Olaia; Ojeda del Pozo, Natalia; Peña Lasa, Javier; Ruppert, Marina C. ; Sala Llonch, Roser ; Theis, Hendrik; Uribe, Carme; Junqué i Plaja, Carme
    Multi-site MRI datasets are crucial for big data research. However, neuroimaging studies must face the batch effect. Here, we propose an approach that uses the predictive probabilities provided by Gaussian processes (GPs) to harmonize clinical-based studies. A multi-site dataset of 216 Parkinson's disease (PD) patients and 87 healthy subjects (HS) was used. We performed a site GP classification using MRI data. The outcomes estimated from this classification, redefined like Weighted HARMonization PArameters (WHARMPA), were used as regressors in two different clinical studies: A PD versus HS machine learning classification using GP, and a VBM comparison (FWE-p <.05, k = 100). Same studies were also conducted using conventional Boolean site covariates, and without information about site belonging. The results from site GP classification provided high scores, balanced accuracy (BAC) was 98.39% for grey matter images. PD versus HS classification performed better when the WHARMPA were used to harmonize (BAC = 78.60%; AUC = 0.90) than when using the Boolean site information (BAC = 56.31%; AUC = 0.71) and without it (BAC = 57.22%; AUC = 0.73). The VBM analysis harmonized using WHARMPA provided larger and more statistically robust clusters in regions previously reported in PD than when the Boolean site covariates or no corrections were added to the model. In conclusion, WHARMPA might encode global site-effects quantitatively and allow the harmonization of data. This method is user-friendly and provides a powerful solution, without complex implementations, to clean the analyses by removing variability associated with the differences between sites.