Examinando por Autor "Etxaniz Oses, Jose"

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    Ítem
    Lived experiences and engagement in an exercise program for people with Resistant Major Depression: TRACE-RMD Study
    (Multidisciplinary Digital Publishing Institute (MDPI), 2026-04-01) Etxaniz Oses, Jose ; Tous Espelosín, Mikel ; Sánchez Gómez, Pedro Manuel ; Maldonado Martín, Sara ; Prada-Perea, Ana Isabel; Iriarte Yoller, Nagore
    Background: Resistant major depression (RMD) is characterized by persistent depressive symptoms despite adequate pharmacological treatment, leading to functional impairment and increased physical comorbidity. Lifestyle interventions, particularly physical activity, are promising adjuncts, yet factors influencing engagement remain poorly understood. Methods: A purposive sampling approach and thematic analysis informed by a socioecological framework were employed to explore participants’ lived experiences after completing a 12-week supervised combined exercise program. Semi-structured interviews were thematically analyzed. Results: Engagement was influenced by three main themes: intrapersonal (symptoms, lifestyle, medication, program expectations), interpersonal (family, peers, healthcare professionals), and environmental (program location, schedule, session design) factors. Motivation was shaped by emotional, physical, and social goals, while barriers included fatigue, anhedonia, and side effects of medication. Conclusions: Engagement in exercise interventions for RMD is shaped by the interaction of personal, social, and environmental factors. Understanding lived experiences can inform the design of person-centered, sustainable interventions.
  • Miniatura
    Ítem
    Treatment with combined exercise in patients with resistant major depression (TRACE-RMD): study protocol for a randomised controlled trial
    (BioMed Central Ltd, 2024-12-18) Iriarte Yoller, Nagore; Etxaniz Oses, Jose; Pavón Navajas, Cristóbal; Tous Espelosín, Mikel; Sánchez Gómez, Pedro Manuel; Maldonado Martín, Sara; Yoller Elburgo, Ana Blanca; Elizagarate Zabala, Edorta
    Background: Around 40% of people with major depressive disorder (MDD) experience moderate remission, with the remainder meeting the criteria for resistant major depression (RMD). It has been shown that exercise has a low-to-moderate effect on MDD, but there is a lack of evidence on exercise interventions in RMD patients. The primary purpose of the proposed study will be to investigate the effect of a 12-week supervised combined exercise program on depressive symptoms in people with RMD compared to a treatment-as-usual (TAU) group. Method: This randomised, single-blind, controlled experimental trial will include 70 adults (≥ 18 years old) with RMD. Participants randomised to an exercise intervention, or a TAU group will be assessed at baseline and after a three-month intervention period. The primary variable will be participants’ depressive symptoms measured with the Montgomery-Asberg Depression Rating Scale. Secondary outcome variables will include cardiorespiratory fitness (peak oxygen uptake through peak cardiopulmonary exercise test), body composition (bioimpedance and anthropometric variables), physical activity level (the International Physical Activity Questionnaire), health-related quality of life (the Short Form-36 Health Survey), functional outcome (the Sheehan Disability Scale and Quality of Life in Depression Scale), overall disease severity (the Clinical Global Impression Scale-Severity of Illness), and biochemical variables (a fasting blood sample). Discussion: This study will try to answer whether a supervised co-adjuvant combined (aerobic and resistance training) exercise program will help the prognosis of this population with RMD. Trial registration: ClinicalTrials.gov NCT05136027.