Examinando por Autor "Elizagarate Zabala, Edorta"

Mostrando 1 - 4 de 4
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    As we were and as we should be, combined exercise training in adults with schizophrenia: CORTEX-SP study part II
    (John Wiley and Sons Inc, 2024-08) Tous Espelosín, Mikel; Pavón, Cristóbal; Elizagarate Zabala, Edorta; Sampedro, Agurne; Maldonado Martín, Sara
    Objective: To determine the changes in health-related quality of life (HRQoL) and sleep quality following a supervised combined exercise (EX) program compared to a Treatment-As-Usual (TAU) and to analyze the relationship between the differences in cardiorespiratory fitness (CRF) and HRQoL domains in people with schizophrenia (SZ). Methods: The SZ (n = 112, 41.3 ± 10.4 year) was randomly assigned into a TAU control group (n = 53) or EX-group (n = 59, 3 days/week). The 36-item Short-Form Health Survey questionnaire assessed HRQoL and the sleep quality analysis (accelerometry). Results: After the intervention (20 weeks), physical functioning (∆ = 12.9%), general health (∆ = 15.3%), mental health (∆ = 8.3%), physical component summary (PCS) (∆ = 5.1%), and sleep efficiency (∆ = 1.9%) increased (p < 0.05) in the EX, with no significant changes in the TAU for any domains studied. There were significant differences between groups whose EX showed improvements (p < 0.05) compared to TAU in physical functioning, general health, PCS, and sleep efficiency. A greater CRF was associated with better values in physical functioning, role-physical, bodily pain, general health, vitality, and PCS after the exercise program in SZ. Conclusions: A 20-week supervised combined exercise intervention program for SZ increased sleep efficiency and physical functioning, general and mental health, and PCS scores. This could lead to a critical HRQoL change from how they were to how they should be. Trial Registration: ClinicalTrials.gov identifier: NCT03509597.
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    Combining social cognitive treatment, cognitive remediation, and functional skills training in schizophrenia: a randomized controlled trial
    (Nature Publishing Group, 2016-11-09) Peña Lasa, Javier ; Ibarretxe Bilbao, Naroa ; Sánchez Gómez, Pedro Manuel ; Iriarte Durán, María B.; Elizagarate Zabala, Edorta; Garay, María A.; Gutiérrez, Manuel; Iribarren, Aránzazu; Ojeda del Pozo, Natalia
    This study examined the efficacy of an integrative cognitive remediation program (REHACOP) in improving cognition and functional outcome in patients with schizophrenia. The program combines cognitive remediation, social cognitive intervention, and functional skills training. Few studies have attempted this approach. One hundred and eleven patients diagnosed with schizophrenia were randomly assigned to either the cognitive remediation group (REHACOP) or an active control group (occupational activities) for 4 months (three sessions per week, 90 min). Primary outcomes were change on general neurocognitive performance and social cognition, including theory of mind (ToM), emotion perception (EP), attributional style, and social perception (SP). Secondary outcomes included changes on clinical symptoms (Positive and Negative Syndrome Scale) and functional outcome (UCSD Performance-Based Skills Assessment and the Global Assessment of Functioning). The trial was registered with clinicaltrials.gov (NCT02796417). No baseline group differences were found. Significant differences were found in the mean change between the REHACOP group and control group in neurocognition (•p2=0.138), SP (•p2=0.082), ToM (•p2=0.148), EP (•p2=0.071), negative symptoms (η•p2=0.082), emotional distress (η•p2=0.136), Global Assessment of Functioning (η•p2=0.081), and UCSD Performance-Based Skills Assessment (η•p2=0.154). The combination of cognitive remediation, social cognitive intervention, and functional skills training demonstrated statistically significant and clinically meaningful changes in neurocognition, social cognition, negative, and functional disability.
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    Cross-validation of predictive equation for cardiorespiratory fitness by modified shuttle walk test in adults with schizophrenia: a secondary analysis of the cortex-sp study
    (MDPI, 2021-10-29) Tous Espelosín, Mikel; Ruiz de Azúa García, Sonia; Iriarte Yoller, Nagore; Sánchez Gómez, Pedro Manuel; Elizagarate Zabala, Edorta; Sampedro, Agurne; Maldonado Martín, Sara
    Cardiorespiratory fitness (CRF) can be direct or estimated from different field tests. The Modified Shuttle Walk Test (MSWT) is suitable for all levels of function, allowing a peak response to be elicited. Therefore, we aimed (1) to validate the equation presented in the original study by Singh et al. for evaluating the relationship between MSWT with peak oxygen uptake (VO2peak) in adults with schizophrenia (SZ), (2) to develop a new equation for the MSWT to predict VO2peak, and (3) to validate the new equation. Participants (N = 144, 41.3 ± 10.2 years old) with SZ performed a direct measurement of VO2peak through a cardiopulmonary exercise test and the MSWT. A new equation incorporating resting heart rate, body mass index, and distance from MSWT (R2 = 0.617; adjusted R2 = 0.60; p < 0.001) performs better than the Singh et al. equation (R2 = 0.57; adjusted R2 = 0.57; p < 0.001) to estimate VO2peak for the studied population. The posteriori cross-validation method confirmed the model’s stability (R2 = 0.617 vs. 0.626). The findings of the current study support the validity of the new regression equation incorporating resting heart rate, body mass index, and distance from MSWT to predict VO2peak for assessment of CRF in people with SZ.
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    Treatment with combined exercise in patients with resistant major depression (TRACE-RMD): study protocol for a randomised controlled trial
    (BioMed Central Ltd, 2024-12-18) Iriarte Yoller, Nagore; Etxaniz Oses, Jose; Pavón Navajas, Cristóbal; Tous Espelosín, Mikel; Sánchez Gómez, Pedro Manuel; Maldonado Martín, Sara; Yoller Elburgo, Ana Blanca; Elizagarate Zabala, Edorta
    Background: Around 40% of people with major depressive disorder (MDD) experience moderate remission, with the remainder meeting the criteria for resistant major depression (RMD). It has been shown that exercise has a low-to-moderate effect on MDD, but there is a lack of evidence on exercise interventions in RMD patients. The primary purpose of the proposed study will be to investigate the effect of a 12-week supervised combined exercise program on depressive symptoms in people with RMD compared to a treatment-as-usual (TAU) group. Method: This randomised, single-blind, controlled experimental trial will include 70 adults (≥ 18 years old) with RMD. Participants randomised to an exercise intervention, or a TAU group will be assessed at baseline and after a three-month intervention period. The primary variable will be participants’ depressive symptoms measured with the Montgomery-Asberg Depression Rating Scale. Secondary outcome variables will include cardiorespiratory fitness (peak oxygen uptake through peak cardiopulmonary exercise test), body composition (bioimpedance and anthropometric variables), physical activity level (the International Physical Activity Questionnaire), health-related quality of life (the Short Form-36 Health Survey), functional outcome (the Sheehan Disability Scale and Quality of Life in Depression Scale), overall disease severity (the Clinical Global Impression Scale-Severity of Illness), and biochemical variables (a fasting blood sample). Discussion: This study will try to answer whether a supervised co-adjuvant combined (aerobic and resistance training) exercise program will help the prognosis of this population with RMD. Trial registration: ClinicalTrials.gov NCT05136027.