Examinando por Autor "Vergara, Itziar"

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    Supervised exercise intervention restores physical activity and MultiOMIC-Derived frailty biomarkers in older adults.
    (John Wiley and Sons Inc, 2026-08-01) Marcos-Pérez, Diego; Cruces Salguero, Sara; Saeteros, Morelva; García Molina, Rafael; Ruben Alcantud-Córcoles; Alonso Bouzón, Cristina; Vergara, Itziar; Sanabria Martín, Sergio José; Rodríguez Mañas, Leocadio; Abizanda, Pedro; Matheu, Ander
    Background: The molecular mechanisms underlying frailty are under intense investigation. Independent observational studies revealed various biological processes and biomarkers differentially expressed in frail individuals and after interventions. Recently, several transcriptomic approaches have described molecular patterns associated with frailty status. However, the effects of physical exercise interventions remain unexplored. Two studies (FRAILOMIC and BIOFRAIL) identified molecular signatures associated with frailty. The objective of the study was to analyse the expression of the FRAILOMIC and BIOFRAIL biomarkers following a multicomponent personalized exercise intervention in older adults. Methods: A multi-centre study included a control (n = 24, with 14 women and 10 men, median age 80 ± 5) and an exercise intervention group (n = 44, with 38 women and 6 men, median age 79 ± 4). The latter underwent a 16-week multicomponent presential physical exercise programme; clinical, functional and frailty assessments were performed before and after the intervention in both groups. Latent class analysis identified ‘responders’ and ‘non-responders’ to the intervention. Data in a testosterone-suppressed control cohort of older men with prostatic cancer receiving androgen deprivation therapy (n = 21) were included. Molecular biomarkers were measured via qRT-PCR and ELISA. Results: The exercise group presented improvements in functional capacity, as shown by Short Physical Performance Battery (SPPB) (post- 10.1 vs. 9.1 in pre-intervention), grip strength (18.3 vs. 16.9 kg), gait speed (0.85 vs. 0.78 m/s), sarcopenia (2.1 vs. 3.0) and frailty status by Fried Frailty Phenotype (1.6 vs 2.1 criteria) (all ≤ 0.004). ANCOVA revealed significant improvements in SPPB (p = 0.04) and grip strength (p < 0.005) with exercise. Four of the six FRAILOMIC biomarkers (miR125b, miR194, RAGE and Troponin) and six of seven BIOFRAIL biomarkers (EGR1, CXCL8, GOS2, NSF, DDX11L1 and miR454) reversed significantly their expression after exercise training (p ≤ 0.05 for FRAIOLMIC and ≤ 0.01 for BIOFRAIL respectively). In contrast, these changes were not observed in testosterone-suppressed controls, who experienced muscle loss. Latent class analysis revealed 36 ‘responders’ (with 32 cases from intervention group) and 29 ‘non-responders’. Logistic regression showed that miR454, EGR1, DDX11L1 and Troponin displayed the strongest predictive value in distinguishing responders from non-responders. Conclusions: Exercise intervention improved functional status and reversed biological frailty, as evidenced by changes in multiple MultiOMIC frailty biomarkers. Among these, the BIOFRAIL trio—miR454, EGR1 and DDX11L1—showed the strongest predictive power for intervention response with AUC of 0.83. This study provides proof-of-concept for the utility of OMIC-derived frailty biomarkers as outcome measures after intervention.
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    Wrist fractures and their impact in daily living functionality on elderly people: a prospective cohort study
    (BioMed Central, 2016-01-14) Vergara, Itziar ; Vrotsou, Kalliopi; Orive Calzada, Miren ; García Gutiérrez, Susana ; González, Nerea; Las Hayas Rodríguez, Carlota ; Quintana, José María
    Background: Wrist fractures are the most common arm fractures in older adults. The impact of wrist fractures on daily functionality has been less studied than that of other types and so, less is known about the complexity of factors related to the functional impact of these fractures. This study is aimed to assess the role of individual and health care factors and its association with daily living functional changes after a wrist fracture. Methods: A prospective cohort of patients aged 65 or more, affected by a fracture due to a fall, was conducted. These patients were identified at the emergency rooms of the six participating hospitals. As independent factors, the following were studied: socio-demographic data, characteristics of the fracture, health-related quality of life, wrist function and provided treatment. The main outcome was functional status measured by the Barthel Index for daily living basic activities and the Lawton Instrumental Activities of Daily Living (IADL) Scale for daily living instrumental activities. Data were collected at baseline just after the fall and after six months of follow-up. Patients were considered to have deteriorated if their functional status as measured by Barthel Index or Lawton IADL scores decreased in a significant way during the six months of follow up. Results: Barthel Index and/or Lawton IADL scores fell at six months after the fracture in 33 % of participants. This functional decline was more frequent in patients with comorbidity (p < 0.0001), polypharmacy (p < 0.0001), low health-related quality of life prior to the fall (p < 0.0001) and lower educational level (p = 0.009). The derived multivariate models show that patients that become dependent six months after the fall, have advanced age, severe chronic diseases, low functional performance prior to the fracture, and repeated episodes of accidental falls. This profile is consistent with a frailty phenotype. Conclusions: Wrist fractures are associated to the occurrence of dependence, especially in frail patients. These patients could benefit from being identified at the time the fracture is treated, in order to tackle their complex needs and so, prevent some of the burden of dependence generated by these fractures.