Examinando por Autor "Muthalib, Makii"

Mostrando 1 - 4 de 4
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    Ítem
    Effects of slow oscillatory HD-tDCS on creative cognition and prefrontal cortex activity: a multimodal EEG-fNIRS study
    (Elsevier B.V., 2026-05) Martínez Martínez, Sarai; Muthalib, Makii; Sampedro, Agurne ; Ojeda del Pozo, Natalia ; Peña Lasa, Javier
    Creativity relies on the dynamic interaction between the default mode (DMN) and frontoparietal control (FPCN) networks, supported by controlled attentional processing and associative strategies. Slow wave activity (SWA: 0.1– 1 Hz) is a critical component of network reorganization during non-REM sleep; while slow oscillatory tDCS (so-tDCS) at 0.75 Hz has been shown to acutely modulate SWA to enhance cognition. This study employed a novel concurrent EEG-fNIRS multimodal imaging approach to investigate whether so-tDCS at 0.75 Hz over the bilateral dorsolateral prefrontal cortex (DLPFC) and medial prefrontal cortex (mPFC) modulates brain oscillations and haemodynamics to promote creativity. Participants (N = 39) completed the Unusual Uses and Picture Completion (PC) creative tasks while receiving sham/so-tDCS at 0.75 Hz using a 2 × 1 high-definition (HD) montage with two anodes (F3, F4) and one cathode (Fpz) for 30 min in a double-blind, sham-controlled, crossover experiment. Compared to sham, so-tDCS significantly increased originality in PC (p = .014, g = 0.40) and was accompanied by sustained increases in oxygenation in the left prefrontal cortex (PFC, p = .003). Post-stimulation, functional connectivity (FC) within left PFC was increased and within right was reduced, accompanied by significantly lower SWA in the left PFC. In addition, asymmetrical fNIRS-derived FC patterns were observed: higher left intrahemispheric PFC (p = .007), and lower interhemispheric PFC (p = .015). These findings suggest that so-tDCS using a HD montage over the bilateral DLPFC and mPFC enhances visual creativity by dynamically adjusting the left PFC resources, which subsequently may trigger downscaling mechanisms.
  • Miniatura
    Ítem
    Enhancement of divergent creative thinking after transcranial near-infrared photobiomodulation over the default mode network
    (Routledge, 2024) Peña Lasa, Javier; Muthalib, Makii; Beaty, Roger E.; Sampedro, Agurne; Ibarretxe Bilbao, Naroa; Zubiaurre Elorza, Leire; García Guerrero, Acebo; Cortazar, Ibon; Niso, Mikel; Ojeda del Pozo, Natalia
    Transcranial photobiomodulation (tPBM) has been used for cognitive enhancement in healthy people. However, its effect on creativity has not been investigated. The default mode network (DMN) is associated with divergent thinking (DT; but not convergent thinking, CT), and also with anxiety, which in turn has been negatively related to creativity. We aimed to use tPBM over the DMN to assess the effect on DT compared to sham. Additionally, we assessed the possible mediating effect of anxiety between tPBM and DT. In this single-blind, between-subjects study, 58 healthy participants were randomly assigned to tPBM or sham group. tPBM was applied using near-infrared light (810 nm, 40 Hz; 50% duty cycle), through light-emitting diode devices combining transcranial plus intranasal PBM over the cortical nodes of the DMN for 20 min (240 J/cm2 in total). DT and CT were assessed before (baseline) and after tPBM with the Unusual Uses (UU), Picture Completion (PC) and Remote Associates test (RAT). ANCOVA (post-stimulation controlling for baseline) results showed that tPBM group had significantly higher scores compared to sham in total UU, PC, and total DT. tPBM may be effective for DT enhancement. The lack of effect on CT reveals a specific link between DMN and DT.
  • Miniatura
    Ítem
    Enhancing creativity with combined transcranial direct current and random noise stimulation of the left dorsolateral prefrontal cortex and inferior frontal gyrus
    (John Wiley and Sons Inc, 2023-03) Peña Lasa, Javier; Muthalib, Makii; Sampedro, Agurne; Cardoso-Botelho, Mafalda; Zabala Gómez, Oihana; Ibarretxe Bilbao, Naroa; García Guerrero, Acebo; Zubiaurre Elorza, Leire; Ojeda del Pozo, Natalia
    Creativity is a fundamental human accomplishment from scientific advances to composing music. The left dorsolateral prefrontal cortex (DLPFC) and inferior frontal gyrus (IFG) are important metacontrol hubs in flexibility and persistence brain states, respectively. Those hubs are related to divergent thinking, insight problem-solving, and convergent thinking. In this double-blind, between-subjects study, 81 healthy participants were randomly assigned to one of three groups (n = 27) that received a combined transcranial direct current stimulation–transcranial random noise stimulation (tDCS-tRNS) protocol with the anode over the left DLPFC and cathode over the left IFG (+DLPFC−IFG), the opposite montage (−DLPFC+IFG), and a sham group (+DLPFC−IFG). Both active tDCS-tRNS groups received 20 min of 1 mA tDCS with 1 mA (100–500 Hz) tRNS. Creativity was assessed before (baseline) and during stimulation with the Unusual Uses, Picture Completion (PC), Remote Association test (RAT), Matchstick Arithmetic (MA), and Nine-dot (ND) problems. Only the +DLPFC−IFG group had significantly higher scores compared with sham in the RAT (p =.009), PC fluency (p =.018), PC originality (p =.007), ND (p =.007), and MA (p =.032). Overall, −DLPFC+IFG had greater scores in all creativity tests compared with sham. Implications from the metacontrol theory are discussed.
  • Miniatura
    Ítem
    The impact of Transcranial Photobiomodulation on the bilateral dorsolateral prefrontal cortex in enhancing convergent thinking and stroop test.
    (John Wiley and Sons Inc, 2026-06-01) Peña Lasa, Javier ; Muthalib, Makii; Beaty, Roger E.; Pérez Arroyuelos, Irune; Sampedro, Agurne; Lucas Jiménez, Olaia; Ibarretxe Bilbao, Naroa ; Ojeda del Pozo, Natalia
    Transcranial photobiomodulation (tPBM) has been employed for cognitive enhancement in healthy individuals. This study aimed to investigate the effects of tPBM applied bilaterally over the dorsolateral prefrontal cortex (DLPFC) on convergent thinking (CT), divergent thinking (DT), and the Stroop test. Additionally, we explored whether Stroop performance mediates the effect of tPBM on creativity. In this double-blind, between-subjects study, 56 healthy participants were randomly assigned to either the tPBM or sham group. tPBM was administered using near-infrared light (810 nm, 40 Hz; 50% duty cycle) over the right and left DLPFC for 20 min. Creativity was assessed at baseline and during stimulation using the Unusual Uses (UU) and Picture Completion (PC) for DT, and the Remote Associates Test (RAT) for CT, and the Stroop test. ANCOVA, controlling for baseline scores, revealed that the tPBM group scored significantly higher than the sham group on the RAT (F = 6.15, p = 0.016) and Stroop (F = 4.89, p = 0.031). However, no significant differences were observed for DT. The findings suggest that tPBM may be effective in enhancing CT, but its effect does not appear to be mediated by improvements in Stroop performance. These results indicate that tPBM could be a promising tool for cognitive enhancement in the healthy population.