Examinando por Autor "Mueller, Sven C."
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Ítem Brain network interactions in transgender individuals with gender incongruence(Academic Press Inc., 2020-02-10) Uribe, Carme; Junqué i Plaja, Carme; Gómez Gil, Esther; Abos Ortega, Alexandra; Mueller, Sven C. ; Guillamon, AntonioFunctional brain organization in transgender persons remains unclear. Our aims were to investigate global and regional connectivity differences within functional networks in transwomen and transmen with early-in-life onset gender incongruence; and to test the consistency of two available hypotheses that attempted to explain gender variants: (i) a neurodevelopmental cortical hypothesis that suggests the existence of different brain phenotypes based on structural MRI data and genes polymorphisms of sex hormone receptors; (ii) a functional-based hypothesis in relation to regions involved in the own body perception. T2*-weighted images in a 3-T MRI were obtained from 29 transmen and 17 transwomen as well as 22 cisgender women and 19 cisgender men. Resting-state independent component analysis, seed-to-seed functional network and graph theory analyses were performed. Transmen, transwomen, and cisgender women had decreased connectivity compared with cisgender men in superior parietal regions, as part of the salience (SN) and the executive control (ECN) networks. Transmen also had weaker connectivity compared with cisgender men between intra-SN regions and weaker inter-network connectivity between regions of the SN, the default mode network (DMN), the ECN and the sensorimotor network. Transwomen had lower small-worldness, modularity and clustering coefficient than cisgender men. There were no differences among transmen, transwomen, and ciswomen. Together these results underline the importance of the SN interacting with DMN, ECN, and sensorimotor networks in transmen, involving regions of the entire brain with a frontal predominance. Reduced global connectivity graph-theoretical measures were a characteristic of transwomen. It is proposed that the interaction between networks is a keystone in building a gendered self. Finally, our findings suggest that both proposed hypotheses are complementary in explaining brain differences between gender variants.Ítem CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment(Nature Research, 2023-12-07) Fernández, Rosa; Zubiaurre Elorza, Leire ; Santisteban, Andrea; Ojeda del Pozo, Natalia ; Collet, Sarah; Kiyar, Meltem; T’Sjoen, Guy; Mueller, Sven C.; Guillamon, Antonio; Pásaro, EduardoGender identity refers to the consciousness of being a man, a woman or other condition. Although it is generally congruent with the sex assigned at birth, for some people it is not. If the incongruity is distressing, it is defined as gender dysphoria (GD). Here, we measured whole-genome DNA methylation by the Illumina © Infinium Human Methylation 850k array and reported its correlation with cortical thickness (CTh) in 22 transgender men (TM) experiencing GD versus 25 cisgender men (CM) and 28 cisgender women (CW). With respect to the methylation analysis, TM vs. CW showed significant differences in 35 CpGs, while 2155 CpGs were found when TM vs. CM were compared. With respect to correlation analysis, TM showed differences in methylation of CBLL1 and DLG1 genes that correlated with global and left hemisphere CTh. Both genes were hypomethylated in TM compared to the cisgender groups. Early onset TM showed a positive correlation between CBLL1 and several cortical regions in the frontal (left caudal middle frontal), temporal (right inferior temporal, left fusiform) and parietal cortices (left supramarginal and right paracentral). This is the first study relating CBLL1 methylation with CTh in transgender persons and supports a neurodevelopmental hypothesis of gender identity.Ítem Characterization of the 1H-MRS metabolite spectra in transgender men with gender dysphoria and cisgender people(MDPI, 2021-06-14) Collet, Sarah ; Bhaduri, Sourav; Kiyar, Meltem; T’Sjoen, Guy; Mueller, Sven C.; Guillamon, AntonioMuch research has been conducted on sexual differences of the human brain to determine whether and to what extent a brain gender exists. Consequently, a variety of studies using different neuroimaging techniques attempted to identify the existence of a brain phenotype in people with gender dysphoria (GD). However, to date, brain sexual differences at the metabolite level using magnetic resonance spectroscopy (1H-MRS) have not been explored in transgender people. In this study, 28 cisgender men (CM) and 34 cisgender women (CW) and 29 transgender men with GD (TMGD) underwent1H-MRS at 3 Tesla MRI to characterize common brain metabolites. Specifically, levels of N–acetyl aspartate (NAA), choline (Cho), creatine (Cr), glutamate and glutamine (Glx), and myo-inositol + glycine (mI + Gly) were assessed in two brain regions, the amygdala-anterior hippocampus and the lateral parietal cortex. The results indicated a sex-assigned at birth pattern for Cho/Cr in the amygdala of TMGD. In the parietal cortex, a sex-assigned at birth and an intermediate pattern were found. Though assessed post-hoc, exploration of the age of onset of GD in TMGD demonstrated within-group differences in absolute NAA and relative Cho/Cr levels, suggestive for a possible developmental trend. While brain metabolite levels in TMGD resembled those of CW, some interesting findings, such as modulation of metabolite concentrations by age of onset of GD, warrant future inquiry.Ítem Comparing emotional working memory in adolescents and young adults with and without depressive symptoms: developmental and psychopathological differences(BioMed Central Ltd, 2022-05-25) Royuela Colomer, Estíbaliz; Wante, Laura; Orue Sola, Izaskun; Braet, Caroline; Mueller, Sven C.Depressive symptoms are associated with working memory impairments. Yet, comparative studies examining working memory across the developmental spectrum in depressed and non depressed cohorts are lacking. This study examined emotional working memory in 74 adolescents (mean age = 14; 21 with depressive symptoms) and 92 adults (mean age = 22; 36 with depressive symptoms). Participants completed two versions of an emotional face n-back task, and either paid attention to the valence of the emotion or the gender. Both tasks were completed at low load (0-back) and high load (2-back). In the high load condition, healthy adolescents showed a bias towards positive faces, both speeding up reaction times (RTs) when emotion was task relevant but slowing RTs when they were task irrelevant. This interaction was neither significant in adolescents with depressive symptoms nor in young adults. Depressive symptoms did not influence RTs in low load. The results indicate that adolescents with depressive symptoms might lack the bias towards positive affective material at high load WM task present in healthy adolescents.Ítem Consensus parameter: research methodologies to evaluate neurodevelopmental effects of pubertal suppression in transgender youth(Mary Ann Liebert Inc., 2020-12-11) Chen, Diane; Strang, John F.; Kolbuck, Victoria D.; Rosenthal, Stephen M.; Wallen, Kim; Waber, Deborah P.; Steinberg, Laurence; Sisk, Cheryl L.; Ross, Judith; Paus, Tomas; Mueller, Sven C.; Mccarthy, Margaret M.; Micevych, Paul E.; Martin, Carol L.; Kreukels, Baudewijntje P.C.; Kenworthy, Lauren; Herting, Megan M.; Herlitz, Agneta; Haraldsen, Ira R.J. Hebold; Dahl, Ronald; Crone, Eveline A.; Chelune, Gordon J.; Burke, Sarah M.; Berenbaum, Sheri A.; Beltz, Adriene M.; Bakker, Julie; Eliot, Lise; Vilain, Eric; Wallace, Gregory L.; Nelson, Eric E.; Garofalo, RobertPurpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pubertal suppression improves mental health functioning. Given the widespread changes in brain and cognition that occur during puberty, a critical question is whether this treatment impacts neurodevelopment. Methods: A Delphi consensus procedure engaged 24 international experts in neurodevelopment, gender development, puberty/adolescence, neuroendocrinology, and statistics/psychometrics to identify priority research methodologies to address the empirical question: is pubertal suppression treatment associated with real-world neurocognitive sequelae? Recommended study approaches reaching 80% consensus were included in the consensus parameter. Results: The Delphi procedure identified 160 initial expert recommendations, 44 of which ultimately achieved consensus. Consensus study design elements include the following: a minimum of three measurement time points, pubertal staging at baseline, statistical modeling of sex in analyses, use of analytic approaches that account for heterogeneity, and use of multiple comparison groups to minimize the limitations of any one group. Consensus study comparison groups include untreated transgender youth matched on pubertal stage, cisgender (i.e., gender congruent) youth matched on pubertal stage, and an independent sample from a large-scale youth development database. The consensus domains for assessment includes: mental health, executive function/cognitive control, and social awareness/functioning. Conclusion: An international interdisciplinary team of experts achieved consensus around primary methods and domains for assessing neurodevelopmental effects (i.e., benefits and/or difficulties) of pubertal suppression treatment in transgender youth.Ítem Data for functional MRI connectivity in transgender people with gender incongruence and cisgender individuals(Elsevier Inc., 2020-05-15) Uribe, Carme; Junqué i Plaja, Carme; Gómez Gil, Esther; Abos Ortega, Alexandra; Mueller, Sven C.; Guillamon, AntonioWe provide T2*-weighted and T1-weighted images acquired on a 3T MRI scanner obtained from 17 transwomen and 29 transmen with gender incongruence; and 22 ciswomen and 19 cismen that identified themselves to the sex assigned at birth. Data from three different techniques that describe global and regional connectivity differences within functional resting-state networks in transwomen and transmen with early-in-life onset gender incongruence are provided: (1) we obtained spatial maps from data-driven independent component analysis using the melodic tool from FSL software; (2) we provide the functional networks interactions of two functional atlases’ seeds from a seed-to-seed approach; (3) and global graph-theoretical metrics such as the smallworld organization, and the segregation and integration properties of the networks. Interpretations of the present dataset can be found in the original article, doi:10.1016/j.neuroimage.2020.116613 [1]. The original and processed nifti images are available in Mendeley datasets. In addition, correlation matrices for the seed-to-seed and graph-theory analyses as well as the graph-theoretical measures were made available in Matlab files. Finally, we present supplementary information for the original article.Ítem Do pictures really say more than a thousand words?: a network approach to early traumatic experience and empathic responding(Taylor and Francis Ltd., 2020-09-25) Mueller, Sven C.; Hudson, Anna R.; Meeus, CarmenBackground: Empathy is essential for interpersonal relationships, yet remains difficult to measure. Some evidence suggests that early traumatic experiences leads to alterations in empathic responding. Objective: This study sought to differentiate connections between subtypes of childhood maltreatment, a pictorial test of affective empathy (PET), and self-reported empathy (Interpersonal Reactivity Index; IRI) by using network analysis approach to investigate the structure of relationships between childhood maltreatment and later empathic responding. Method: 301 participants completed the PET, the Early Trauma Inventory Self Report-Short Form (ETISR-SF), the IRI, and questionnaires assessing current mood and perceived stress levels. Results: The PET showed a strong positive association with the IRI subscale empathic concern (EC), after conditioning on all other nodes in the network. EC proved to be a highly central node and was positively related to severity of childhood sexual abuse (CSA), yet not to childhood physical abuse or emotional maltreatment. Pathways between emotional maltreatment and physical abuse and the PET were indirect, passing through self-reported EC and CSA. Conclusions: Our study suggests that CSA more so than other childhood maltreatment experiences is associated with increased self-reported affective empathy, but is not captured directly through a pictorial test of affective empathy.Ítem Effects of an incremental theory of the personality intervention on psychophysiological responses to social stress during the transition to college(Springer, 2023-05) Calvete Zumalde, Esther ; Orue Sola, Izaskun ; Prieto Fidalgo, Ángel ; Gómez Odriozola, Joana; Mueller, Sven C.; Royuela Colomer, Estíbaliz ; Morea, Aida ; Ruiz Alonso, Eneko; Larrucea Iruretagoyena, Maite; Little, T.D.; Fernández González, LiriaThis randomized controlled trial (NCT04786496) examined the effects of a preventive intervention based on Incremental Theory of the Personality (ITP) on psychophysiological responses to social stress and evaluated whether levels of depression moderate the intervention effects. The participants, 107 first-year university students, were randomly assigned to one of three conditions: ITP intervention, ITP + a self-affirmation intervention (SA), and a control condition (CC). Indicators of the Hypothalamic–Pituitary–Adrenal axis, autonomic nervous system, and subjective mood were assessed with the Trier Social Stress Task. Participants in the ITP condition displayed a lower decline in respiratory sinus arrythmia (RSA) compared to those in the CC during the first phases of the task [Slopes: -0.08 (0.09) vs -0.21 (0.09), z = 2.86, p =.004] and a higher decrease in cortisol at recovery [β = -0.18 (0.08), z = -2.37, p =.018]. Depressive symptoms moderated the effect of ITP [β = -0.10 (0.05), z = -2.15, p =.032] and ITP+SA [β = -0.09 (0.04), z = -2.06, p =.039] in the decline during stress and recovery in RSA. In participants with low/medium levels of depressive symptoms, both interventions predicted a lower decline during stress [Slopes: -0.06 (0.09) for ITP, -0.17 (.09) for ITP+SA, and -0.26 (0.09) for CC] and higher recovery in RSA [Slopes: 0.18 (0.01) for ITP, 0.24 (0.01) for ITP+SA, and 0.30 (0.01) for CC]. The findings suggest that the ITP intervention has the potential to be an effective preventive intervention to reduce the stress response.Ítem Reliability of an interpretation bias task of ambiguous faces and its relationship with social anxiety, depression, and looming maladaptive style(Springer Science and Business Media Deutschland GmbH, 2023-03) Prieto Fidalgo, Ángel; Mueller, Sven C. ; Calvete Zumalde, EstherSocial anxiety (SA) and depression have been associated with negative interpretation biases of social stimuli. Studies often assess these biases with ambiguous faces, as people with SA and depression tend to interpret such faces negatively. However, the test–retest reliability of this type of task is unknown. Our objectives were to develop a new interpretation bias task with ambiguous faces and analyse its properties in terms of test–retest reliability and in relation to SA, depression, and looming maladaptive style (LMS). Eight hundred sixty-four participants completed a task in which they had to interpret morphed faces as negative or positive on a continuum between happy and angry facial expressions. In addition, they filled out scales on SA, depressive symptoms, and LMS. Eighty-four participants completed the task again after 1–2 months. The test–retest reliability was moderate (r =.57–.69). The data revealed a significant tendency to interpret faces as negative for people with higher SA and depressive symptoms and with higher LMS. Longer response times to interpret the happy faces were positively associated with a higher level of depressive symptoms. The reliability of the present task was moderate. The results highlight associations between the bias interpretation task and SA, depression, and LMS.